A pilot study evaluating the prognostic utility of platelet indices in dogs with septic peritonitis
A pilot study evaluating the prognostic utility of platelet indices in dogs with septic peritonitis
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DOI：
10.1111/ve
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发表时间：
2017-09-01
影响因子：
1.3
通讯作者：
Rendahl, Aaron
中科院分区：
文献类型：
--
作者：
Llewellyn, Efa A.;Todd, Jeffrey M.;Rendahl, Aaron
ObjectiveTo：探讨犬感染性腹膜炎诊断时的血小板指标，并评估手术治疗犬血小板参数数据与存活至出院的关系。DesignRetrospective，observational，descriptive pilot study from 2009 to 2014. SettingUniversity teaching hospital. Animals本研究纳入48只诊断为感染性腹膜炎的犬。36只狗进行了手术源控制。从46个健康对照犬的血液样本被用于参考区间（RI）generation.InterventionsNone.测量和主要ResultsDogs与脓毒性腹膜炎有显着增加的平均血小板体积（MPV），血小板压积（PCT），血小板分布宽度（PDW）的平均值与增加的比例的狗具有高于RI的值相比，健康的狗。感染性腹膜炎犬的血小板计数高于RI（12.5%）和低于RI（8.3%）的比例显著增加，与健康犬相比，平均血小板计数无显著差异。在手术源控制的存活犬和非存活犬之间，平均血小板计数、MPV、PCT或PDW无显著差异;然而，MPV值高于RI的犬的死亡率显著高于RI内的犬（P = 0.025）。RI以外的其他血小板参数的值与mortality.ConclusionsDogs的显着差异无相关性，脓毒性腹膜炎的血小板增多和血小板减少的频率增加，MPV，PCT，和PDW。MPV增加可能是手术治疗犬死亡风险增加的有用指标。
ObjectiveTo characterize platelet indices at time of diagnosis of septic peritonitis in dogs and to assess the relationship between platelet parameter data and survival to discharge in dogs treated surgically.DesignRetrospective, observational, descriptive pilot study from 2009 to 2014.SettingUniversity teaching hospital.AnimalsForty-eight dogs diagnosed with septic peritonitis were included in this study. Thirty-six dogs had surgical source control. Blood samples from 46 healthy control dogs were used for reference interval (RI) generation.InterventionsNone.Measurements and Main ResultsDogs with septic peritonitis had significantly increased mean values for mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) with increased proportions of dogs having values above the RI compared to healthy dogs. A significantly increased proportion of dogs with septic peritonitis had platelet counts above (12.5%) and below (8.3%) the RI, with no significant difference in mean platelet count compared to healthy dogs. No significant differences in the mean platelet count, MPV, PCT, or PDW were found between survivors and nonsurvivors in dogs with surgical source control; however, dogs with MPV values above the RI had significantly increased mortality compared to dogs within the RI (P = 0.025). Values outside the RI for other platelet parameters were not associated with significant differences in mortality.ConclusionsDogs with septic peritonitis have increased frequency of thrombocytosis and thrombocytopenia with increased MPV, PCT, and PDW. An increased MPV may be a useful indicator of increased risk of mortality in dogs treated surgically.