Cortical Hypometabolism and its Recovery following Nucleus Basalis Lesions in Baboons: A PET Study
Cortical Hypometabolism and its Recovery following Nucleus Basalis Lesions in Baboons: A PET Study
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狒狒基底核损伤后皮质代谢减退及其恢复：PET 研究
DOI：
10.1038/jcbfm.1987.139
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发表时间：
1987
影响因子：
6.3
通讯作者：
J. Baron
中科院分区：
文献类型：
--
作者：
M. Kiyosawa;S. Pappatà;D. Duverger;D. Riche;H. Cambon;B. Mazoyer;Y. Samson;C. Crouzel;R. Naquet;E. Mackenzie;J. Baron
采用正电子发射断层扫描和[18 F]氟脱氧葡萄糖对5只狒狒进行葡萄糖脑代谢率连续测定，并对Meynert左基底核（NbM）进行立体定向电凝。损伤后4天，在同侧大脑皮层中存在显著的代谢抑制，在额颞区最明显，并在6-13周内逐渐恢复。这些数据表明，自适应机制有效地补偿了皮层代谢的影响NbM损伤引起的胆碱能去传入。此外，单侧NbM病变也引起对侧皮质代谢率的短暂降低，其机制进行了讨论。解释灵长类动物胆碱能神经传入阻滞的这些作用，可以进一步加深我们对阿尔茨海默型痴呆症中所观察到的代谢缺陷的理解。
The cerebral metabolic rate for glucose was measured serially with positron emission tomography and [18F]fluorodeoxyglucose in five baboons with stereotactic electrocoagulation of the left nucleus basalis of Meynert (NbM). Four days after lesion, a significant metabolic depression was present in the ipsilateral cerebral cortex, most marked in the frontotemporal region, and which recovered progressively within 6–13 weeks. These data demonstrate that adaptive mechanisms efficiently compensate for the cortical metabolic effects of NbM-lesion-induced cholinergic deafferentation. Moreover, unilateral NbM lesions also induced a transient reduction in contralateral cortical metabolic rate, the mechanisms of which are discussed. Explanation of these effects of cholinergic deafferentation in the primate could further our understanding of the metabolic deficits observed in dementia of the Alzheimer's type.
大鼠腹内侧苍白球的鹅膏酯损伤后皮质葡萄糖利用率降低。
DOI：
10.1038/jcbfm.1984.56
发表时间：
1984
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
London,ED;McKinney,M;Dam,M;Ellis,A;Coyle,JT
通讯作者：
Coyle,JT