Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases
Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases
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DOI：
10.1016/j.phrs.2023.106820
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发表时间：
2023-06-13
影响因子：
9.3
通讯作者：
Yang，Haixia
中科院分区：
文献类型：
--
作者：
Zhao，Tong;Zhu，Yuchen;Yang，Haixia
荷叶碱阿朴啡类生物碱主要存在于荷叶中，具有抗肥胖、降血脂、预防糖尿病和癌症等有益于人体健康的作用，与炎症密切相关。重要的是，荷叶碱可以通过在多种模型中发挥强烈的抗炎活性来促进其生物活性。然而，目前尚无文献综述荷叶碱的抗炎作用。本文批判性地总结了有关膳食荷叶碱结构与活性关系的信息。此外，还综述了其在肥胖、糖尿病、肝脏、心血管疾病和癌症等炎症相关疾病中的生物活性和临床应用，以及其潜在的机制，包括氧化应激、代谢信号和肠道微生物群。目前的工作提供了对荷叶碱对多种疾病的抗炎特性的更好理解，从而提高含荷叶碱植物在功能性食品和药物中的利用和应用。
Nuciferine aporphine alkaloid mainly exists inNelumbo nuciferaGaertn and is a beneficial to human health, such as anti-obesity, lowering blood lipid, prevention of diabetes and cancer, closely associated with inflammation. Importantly, nuciferine may contribute to its bioactivities by exerting intense anti-inflammatory activities in multiple models. However, no review has summarized the anti-inflammatory effect of nuciferine. This review critically summarized the information regarding the structure-activity relationships of dietary nuciferine. Moreover, biological activities and clinical application on inflammation-related diseases, such as obesity, diabetes, liver, cardiovascular diseases, and cancer, as well as their potential mechanisms, involving oxidative stress, metabolic signaling, and gut microbiota has been reviewed. The current work provides a better understanding of the anti-inflammation properties of nuciferine against multiple diseases, thereby improving the utilization and application of nuciferine-containing plants across functional food and medicine.