Channelling inflammation: gasdermins in physiology and disease.
Channelling inflammation: gasdermins in physiology and disease.
复制标题
DOI：
10.1038/s41573-021-00154-z
复制
发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Lieberman J
中科院分区：
文献类型：
--
作者：
Liu X;Xia S;Zhang Z;Wu H;Lieberman J
最近，Gasdermins被确认为炎性细胞死亡的介体，由胞浆对侵袭性感染和危险信号的感知而触发。当被激活时，气囊会形成细胞膜孔隙，释放促炎细胞因子和警报蛋白，破坏细胞膜的完整性。气囊蛋白在自身免疫和炎症性疾病、传染病、耳聋和癌症中的作用正在显现，揭示了潜在的新的治疗途径。在这里，我们回顾了目前关于气囊藻类家族的知识，重点介绍了它们的作用机制和在正常生理和疾病中的作用。强调了开发药物来调节Gasdermin活性以减少炎症或激活更有效的免疫反应的努力。Gasdermins(GSDM)是最近鉴定的一个蛋白家族，它介导一种称为上睑下垂的程序性炎性细胞死亡。在这里，Lieberman和他的同事回顾了目前对GSDM的表达、激活和调节的理解，强调了它们在细胞死亡、细胞因子分泌和炎症中的作用。重点介绍了开发GSDM靶向药物的新机遇和相关挑战。
Gasdermins were recently identified as the mediators of pyroptosis — inflammatory cell death triggered by cytosolic sensing of invasive infection and danger signals. Upon activation, gasdermins form cell membrane pores, which release pro-inflammatory cytokines and alarmins and damage the integrity of the cell membrane. Roles for gasdermins in autoimmune and inflammatory diseases, infectious diseases, deafness and cancer are emerging, revealing potential novel therapeutic avenues. Here, we review current knowledge of the family of gasdermins, focusing on their mechanisms of action and roles in normal physiology and disease. Efforts to develop drugs to modulate gasdermin activity to reduce inflammation or activate more potent immune responses are highlighted. Gasdermins (GSDMs) are a recently characterized protein family that mediate a programmed inflammatory cell death termed pyroptosis. Here, Lieberman and colleagues review current understanding of the expression, activation and regulation of GSDMs, highlighting their roles in cell death, cytokine secretion and inflammation. Emerging opportunities to develop GSDM-targeted drugs and the associated challenges are highlighted.
登录
查看更多内容
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
5.7
作者：
Akino, Kimishige;Toyota, Minoru;Tokino, Takashi
通讯作者：
Tokino, Takashi
影响因子：
4.5
作者：
Carl-Mcgrath, Stacy;Schneider-Stock, Regine;Roecken, Christoph
通讯作者：
Roecken, Christoph
影响因子：
3.6
作者：
Brennan, MA;Cookson, BT
通讯作者：
Cookson, BT
影响因子：
3.5
作者：
Cheng, J.;Han, D. Y.;Yuan, H. J.
通讯作者：
Yuan, H. J.