COMPARATIVE HEMATOLOGICAL AND PLASMA CHEMISTRY VALUES IN PURPOSE-BRED SQUIRREL, CYNOMOLGUS AND RHESUS-MONKEYS
COMPARATIVE HEMATOLOGICAL AND PLASMA CHEMISTRY VALUES IN PURPOSE-BRED SQUIRREL, CYNOMOLGUS AND RHESUS-MONKEYS
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DOI：
10.1007/bf00368266
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
NAGAI, Y
中科院分区：
文献类型：
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作者：
MATSUZAWA, T;NAGAI, Y
我们对三种专门饲养的灵长类动物——恒河猴、食蟹猴、松鼠猴——的血液学和血液化学数据进行了比较。这些物种在我们的灵长类动物设施中在相同的条件（饮食、自来水、室温和相对湿度以及照明条件）下饲养了 9 个月。使用相同的分析前条件（采血程序、抗凝剂和样品储存）和分析方法（试剂和设备）进行血液和尿液测定。结果表明，松鼠、恒河猴和食蟹猴的所有检查参数具有基本生物学相似的值。然而，食蟹猴的血红蛋白水平、网织红细胞、血浆总胆固醇、甘油三酯、白蛋白和尿素氮值以及尿渗透压在统计学上低于恒河猴。食蟹猴的红细胞计数、血浆ALT、钙和钾在统计学上高于恒河猴。食蟹猴的红细胞计数、血红蛋白水平、红细胞压积、网织红细胞、血浆总胆红素和氯化物以及尿渗透压均显着低于松鼠猴。食蟹猴的白细胞计数、血浆总蛋白、白蛋白和钙均显着高于松鼠猴。松鼠猴在四项检测中与其他两个物种表现出明显偏差：淋巴细胞与中性粒细胞的比率、AST、ALT 和尿量。本研究获得的结果将用作三种专门饲养的猴子的血液学和临床化学特征的基线数据。
Haematological and blood chemistry data have been compared for three species of purpose-bred primates, Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus monkey), Saimiri sciureus (squirrel monkey). These species were housed over a 9-month period in identical conditions (diet, tap water, room temperature and relative humidity, and lighting regime) in our primate facility. Blood and urine assays were conducted using the same pre-analytical conditions (blood sampling procedure, anticoagulant and storage of sample), and analytical methods (reagent and equipment).The results indicated that squirrel, rhesus and cynomolgus monkeys have essentially biologically similar values for all of the parameters examined. However, haemoglobin level, reticulocyte, plasma total cholesterol, triglyceride, albumin and urea nitrogen values, and urinary osmolality in cynomolgus monkeys were statistically lower than those of rhesus monkeys. Erythrocyte count, plasma ALT, calcium and potassium in cynomolgus monkeys were statistically higher than those of rhesus monkeys. Erythrocyte count, haemoglobin level, haematocrit, reticulocyte, plasma total bilirubin and chloride and urinary osmolality in cynomolgus monkeys were statistically lower than those of squirrel monkeys. Leucocyte count, plasma total protein, albumin and calcium in cynomolgus monkeys were statistically higher than those of squirrel monkeys. Squirrel monkeys showed marked deviations in four assays from the other two species: ratio of lymphocytes to neutrophils, AST, ALT and urine volume.The results obtained in this study will be used as baseline data for haematology and clinical chemistry characteristics for three species of purpose-bred monkeys.