Roles for RACK1 in cancer cell migration and invasion
Roles for RACK1 in cancer cell migration and invasion
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DOI：
10.1016/j.cellsig.2017.03.005
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发表时间：
2017-07-01
影响因子：
4.8
通讯作者：
Long, Aideen
中科院分区：
文献类型：
--
作者：
Duff, Deirdre;Long, Aideen
癌细胞迁移和侵入周围组织和脉管系统是癌症转移的重要初始步骤。转移是癌症相关死亡的主要原因，因此我们必须提高对促进这种危及生命现象的机制的理解。细胞迁移涉及一个复杂的多步骤过程，导致肌动蛋白驱动的细胞在身体组织上或通过身体组织的运动。多功能支架蛋白RACK1在成核细胞信号枢纽、将蛋白锚定在特定的亚细胞位置和调节蛋白活性方面发挥重要作用。RACK 1对细胞迁移至关重要，越来越多的证据表明RACK 1在调节肿瘤细胞的迁移和侵袭中具有多种作用。设计阻断癌细胞迁移和侵袭能力的药物的可能性代表了用于治疗恶性疾病的有吸引力的治疗策略，其中RACK 1是潜在的靶点。在这篇综述中，我们总结了这些证据，并研究了RACK 1的贡献的各个阶段的细胞迁移和入侵的机制。(C)2017爱思唯尔公司All rights reserved.
Migration and invasion of cancer cells into surrounding tissue and vasculature is an important initial step in cancer metastasis. Metastasis is the leading cause of cancer related death and thus it is crucial that we improve our understanding of the mechanisms that promote this life-threatening phenomenon. Cell migration involves a complex, multistep process that leads to the actin-driven movement of cells on or through the tissues of the body. The multifunctional scaffolding protein RACK1 plays important roles in nucleating cell signalling hubs, anchoring proteins at specific subcellular locations and regulating protein activity. It is essential for cell migration and accumulating evidence now demonstrates multiple roles for RACK1 in regulating migration and invasion of tumour cells. The possibility of designing drugs that block the migratory and invasive capabilities of cancer cells represents an attractive therapeutic strategy for treating malignant disease with RACK1 being a potential target. In this review we summarize this evidence and examine the mechanisms that underlie the contribution of RACK1 to the various stages of cell migration and invasion. (C) 2017 Elsevier Inc. All rights reserved.