Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.
Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.
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β淀粉样蛋白前体可能是硫酸乙酰肝素蛋白聚糖核心蛋白。
DOI：
10.1126/science.2968652
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Cole,G
中科院分区：
文献类型：
--
作者：
Schubert,D;Schroeder,R;LaCorbiere,M;Saitoh,T;Cole,G
淀粉样β蛋白肽是阿尔茨海默病淀粉样斑块核心的主要成分，显然来源于较高分子量的前体。现在表明，神经细胞系（PC 12）分泌的硫酸乙酰肝素蛋白聚糖的核心蛋白具有与淀粉样β蛋白前体非常相似的氨基酸序列和大小，并且这些分子具有抗原相关性。在不分泌硫酸乙酰肝素蛋白聚糖的变异细胞系（F3 PC12）的条件培养基中未发现这种淀粉样β蛋白转运蛋白相关蛋白。这类蛋白聚糖的突触定位和代谢与其在中枢神经系统功能障碍中的潜在参与一致。
The amyloid β protein peptide is a major constituent of amyloid plaque cores in Alzheimer's disease and is apparently derived from a higher molecular weight precursor. It is now shown that the core protein of a heparan sulfate proteoglycan secreted from a nerve cell line (PC12) has an amino acid sequence and a size very similar to those of the amyloid β protein precursor and that these molecules are antigenically related. This amyloid β protein precursor-related protein is not found in the conditioned medium of a variant cell line (F3 PC12) that does not secrete heparan sulfate proteoglycan. The synaptic localization and metabolism of this class of proteoglycans are consistent with its potential involvement in central nervous system dysfunction.