Examining the Relationship between Cancer Invasion/Metastasis and Drug Resistance
Examining the Relationship between Cancer Invasion/Metastasis and Drug Resistance
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DOI：
10.2174/1568009023333872
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发表时间：
2002-01-01
影响因子：
3
通讯作者：
Clynes, M.
中科院分区：
文献类型：
--
作者：
Liang, Y.;McDonnell, S.;Clynes, M.
肿瘤侵袭/转移和耐药性的研究在过去通常沿着不同的研究途径进行。然而，最近的兴趣已经集中在耐药性与肿瘤侵袭和转移之间的可能关系。这两种表型之间的关系已通过两种类型的观察得到证实：首先，一些选择耐药的肿瘤细胞相对于非耐药亲本细胞更具侵袭性/转移性;其次，在某些情况下，继发性（更具转移性）肿瘤比其原发性对应物对化疗药物更具耐药性。在文献中报告的其他情况下，未观察到药物暴露/耐药性与癌症侵袭/转移之间的相关性。一些化疗药物治疗可能能够促进癌症侵袭和转移的可能性需要进一步研究，因为其潜在的临床意义。更好地了解耐药性和癌症侵袭之间的任何关系可能会导致更有效的癌症治疗。
Studies of cancer invasion/metastasis and drug resistance have in the past generally proceeded along the separate pathways of research. Recently, however, interest has been focused on the possible relationship between drug resistance and cancer invasion and metastasis. A relationship between these two phenotypes has been demonstrated by two types of observation: firstly, some tumor cells selected for resistance to drugs are more invasive/metastatic relative to non-resistant parental cells; secondly, in some cases, secondary (more metastatic) tumors are more resistant to chemotherapeutic drugs than their primary counterparts. In other instances reported in the literature, no correlation is seen between drug exposure/resistance and cancer invasion/metastasis. The possibility that treatment with some chemotherapeutic drugs may be able to promote cancer invasion and metastasis needs further investigation because of its potential clinical relevance. A better understanding of any relationship between drug resistance and cancer invasion could lead to more effective cancer treatment.