Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.
Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.
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编码 II 类组织相容性抗原的不变伽马链的人类基因的结构。
DOI：
10.1093/nar/13.24.8827
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发表时间：
1985
影响因子：
14.9
通讯作者：
Saunders,GF
中科院分区：
文献类型：
--
作者：
Kudo,J;Chao,LY;Narni,F;Saunders,GF
测定了慢性淋巴细胞白血病中选择性表达基因的cDNA和基因组DNA的一级结构。计算机检索核苷酸序列数据库，确定该基因为与II类组织相容性抗原相关的不变γ链。不变的γ链基因组序列跨越约11个内切酶，具有8个外显子和7个内含子。其中三个内含子含有重复序列家族的成员。在该基因的5′端鉴定了一个假定的帽位点和启动子序列。每个单倍体基因组中存在一个或两个基因拷贝，没有获得扩增或多态性的证据。
The primary structures of a cDNA and the genomic DNA of a gene selectively expressed in chronic lymphocytic leukemia were determined. A computer search of the nucleotide sequence data bank identified this gene as the invariant γ-chain associated with class II histoeompatibility antigens. The invariant γ-chain genomic sequence spans about 11 kilobases, with eight exons and seven introns. Three of the introns contain members of theAlurepeat family. A putative cap site and promoter sequence were identified at the 5′ end of the gene. One or two copies of the gene is present in each haploid genome, and no evidence for amplification or polymorphism was obtained.