Childhood and adolescent mental health of NICU graduates: an observational study
Childhood and adolescent mental health of NICU graduates: an observational study
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DOI：
10.1136/archdischild-2019-318284
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发表时间：
2020-07-01
影响因子：
5.2
通讯作者：
Van Lieshout, Ryan J.
中科院分区：
文献类型：
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作者：
Chiorean, Andreea;Savoy, Calan;Van Lieshout, Ryan J.
目的 调查入住新生儿重症监护病房 (NICU) 的婴儿期儿童和青少年的心理健康状况。 方法 这项横断面研究使用了 2014 年安大略省儿童健康研究中的省级代表性队列。家长使用 MINI 国际儿童和青少年神经精神病学访谈提供了 3141 名 4-11 岁儿童（NICU n=389；对照 n=2752）和 2379 名 12-17 岁儿童（NICU n=298；对照 n=2081）的精神疾病数据。此外，2235 名 12-17 岁青少年自行完成了访谈（NICU n=285；对照组 n=1950）。比较了入院患者和对照组的精神疾病发生率。 结果 根据家长报告，4-11 岁 NICU 毕业生任何精神疾病的调整 OR (95% CI) 均增加至 1.78（1.39 至 2.28），NICU 参与者的边缘患病率为 32.4%，对照组为 27.6%。在这个年龄，NICU 毕业生的精神合并症的 OR 也增加了 1.74（1.25 至 2.40），对立违抗障碍为 1.48（1.04 至 2.11），注意力缺陷多动障碍为 1.61（1.19 至 2.19），分离焦虑障碍为 4.11（2.33 至 7.25）， 2.13（1.37 至 3.31）针对特定恐惧症。在 12-17 岁时，根据父母的报告和自我报告，分别有 40.5% 和 30.5% 的 NICU 毕业生以及 30.6% 和 17.9% 的对照组患有任何精神疾病。父母和青少年报告称，任何疾病的调整 OR 值 (95% CI) 分别增加为 1.63（1.18 至 2.26）和 1.55（1.13 至 2.11），精神合并症的调整 OR 值分别为 1.64（1.06 至 2.54）和 1.74（1.11 至 2.73），以及 1.89（1.22 至 2.73）。 2.93）和3.17（2.03至4.95）对立违抗性障碍。结论 NICU毕业生在儿童期和青春期患精神疾病的风险增加。
Objective To investigate the mental health of children and adolescents admitted to neonatal intensive/special care units (NICUs) in infancy.Methods This cross-sectional study used a provincially representative cohort from the 2014 Ontario Child Health Study. Parents provided data on psychiatric disorders using the MINI International Neuropsychiatric Interview for Children and Adolescents in 3141 children aged 4-11 years (NICU n=389; control n=2752) and in 2379 children aged 12-17 years (NICU n=298; control n=2081). Additionally, 2235 adolescents aged 12-17 years completed the interview themselves (NICU n=285; control n=1950). Odds of psychiatric disorder were compared in those admitted and controls.Results Based on parent reports, NICU graduates aged 4-11 years had increased adjusted ORs (95% CI) of 1.78 (1.39 to 2.28) for any psychiatric disorder, with a marginal prevalence of 32.4% in NICU participants and 27.6% in controls. At this age, NICU graduates also had increased ORs of 1.74 (1.25 to 2.40) for psychiatric comorbidity, 1.48 (1.04 to 2.11) for oppositional defiant disorder, 1.61 (1.19 to 2.19) for attention-deficit hyperactivity disorder, 4.11 (2.33 to 7.25) for separation anxiety disorder and 2.13 (1.37 to 3.31) for specific phobia. At 12-17 years, 40.5% and 30.5% of NICU graduates and 30.6% and 17.9% of controls had any psychiatric disorder as reported by parents and self-report, respectively. Parents and adolescents, respectively, reported increased adjusted ORs (95% CI) of 1.63 (1.18 to 2.26) and 1.55 (1.13 to 2.11) for any disorder, 1.64 (1.06 to 2.54) and 1.74 (1.11 to 2.73) for psychiatric comorbidity, and 1.89 (1.22 to 2.93) and 3.17 (2.03 to 4.95) for oppositional defiant disorder.Conclusions NICU graduates are at increased risk for psychiatric disorders during childhood and adolescence.