Effects of administration of glucosamine and chicken cartilage hydrolysate on rheumatoid arthritis in SKG mice
Effects of administration of glucosamine and chicken cartilage hydrolysate on rheumatoid arthritis in SKG mice
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葡萄糖胺和鸡软骨水解物给药对 SKG 小鼠类风湿性关节炎的影响
DOI：
10.1039/c9fo00981g
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发表时间：
2019
期刊：
影响因子：
6.1
通讯作者：
Shin Kamiyama
中科院分区：
文献类型：
--
作者：
Shoko Kashiuchi;Rikako Miyazawa;Honoka Nagata;Mayu Shirai;Muneshige Shimizu;Hideyuki Sone;Shin Kamiyama
补充软骨成分，如葡糖胺、硫酸软骨素和胶原肽，被认为可以减轻与关节疾病如类风湿性关节炎（RA）相关的疼痛。在这里，我们每天给药，10毫克葡萄糖胺或100毫克鸡软骨水解物（CH）的SKG/Jcl小鼠，自发性RA模型，5周，并评估其对RA发展的影响。在SKG小鼠中，给予氨基葡萄糖对RA评分没有降低作用，但抑制了关节软骨中Mmp 13和Col 3a 1基因的表达。相比之下，CH的管理抑制RA评分和血浆白细胞介素-6和白细胞介素-17的水平减半，虽然差异不显着。氨基葡萄糖组小鼠股骨骨强度下降，氨基葡萄糖与CH合用可消除上述不良反应。提示CH和氨基葡萄糖对SKG小鼠的作用是不同的。
Supplementation with cartilage constituents, such as glucosamine, chondroitin sulfate and collagen peptide, are believed to reduce pain associated with joint disorders, such as rheumatoid arthritis (RA). Here, we administered daily, 10 mg glucosamine or 100 mg chicken cartilage hydrolysate (CH) to SKG/Jcl mice, a model for spontaneous RA, for 5 weeks and evaluated their effects on RA development. In SKG mice, the administration of glucosamine had no reducing effect on RA score but suppressed the expression of Mmp13 and Col3a1 genes in articular cartilage. In contrast, administration of CH suppressed the RA score and levels of plasma interleukin-6 and interleukin-17 to half, although the differences were not significant. Mice administered with glucosamine also showed decreased bone strength of femur and these adverse effects could be eliminated when glucosamine was used in conjunction with CH. These results suggest that CH and glucosamine exert effects on different aspects in SKG mice.