Inhibitory control of saccadic eye movements and cognitive impairment in Alzheimer's disease
Inhibitory control of saccadic eye movements and cognitive impairment in Alzheimer's disease
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DOI：
10.1016/j.biopsych.2005.01.017
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发表时间：
2005-05-01
影响因子：
10.6
通讯作者：
Tetley, S
中科院分区：
文献类型：
--
作者：
Crawford, TJ;Higham, S;Tetley, S
背景。本研究探讨了抑制控制与早期阿尔茨海默病（AD）患者神经心理损害的关系。本研究解决了以下四个具体问题：1)跳眼抑制的哪些错误参数对AD敏感？2)哪些抑制缺陷与认知功能障碍有关？3) AD的抑制性损伤是否依赖于自发性眼动的开始？4)跳眼抑制控制在AD中的作用与衰老的正常作用有何关系？方法：18名疑似AD患者和2个对照组（17名年轻参与者和18名老年参与者）完成了一系列神经心理测试和4种眼跳运动范式：前扫视、不扫视、扫视/不扫视和反扫视。结果：在GO/NO-GO范式中，与年轻对照相比，老年对照产生了更多的抑制错误。与旧对照组相比，AD在前扫视范式中产生正常的扫视，但在NO-GO、GO/NO-GO和反范式中显示出更高比例的抑制错误。反扫视范式中未纠正错误的频率与痴呆的认知测量呈正相关。结论：AD患者抑制控制和纠错功能的损害超过了正常衰老的影响，与老年痴呆的发生有关。然而，抑制性损伤并不取决于与意志扫视的相互作用。
Background. This study examined the relationship of inhibitory control and measures of neuropsychological impairment inpatients with early Alzheimer's disease (AD). Four specific questions were addressed: 1) Which error parameters of saccadic inhibition are sensitive to AD? 2) Which inhibitory deficits are related to cognitive measures of impairment? 3) Is the inhibitory impairment in AD dependent on the initiation of a volitional eye movement? 4) How do the effects of saccadic inhibitory control in AD relate to the normal effects of aging?Methods: Eighteen patients with probable AD and two control groups (seventeen young, and eighteen old participants) completed a battery of neuropsychological tests and four saccadic eye movement paradigms: pro-saccade, NO-GO, GO/NO-GO and anti-saccade.Results: Old controls generated increased inhibition errors in comparison to young controls in the GO/NO-GO paradigm. In comparison to old controls, AD generated normal saccades in the pro-saccade paradigm, but showed a higher proportion of inhibition errors in the NO-GO, GO/NO-GO and anti-paradigms. The frequency of uncorrected errors in the anti-saccade paradigm was positively correlated with cognitive measures of dementia.Conclusions: AD patients have an impairment of inhibitory control and error-correction that exceeds the effects of normal aging and is related to the seventy of dementia. However, the inhibitory impairment is not contingent on the interaction with a volitional saccade.