Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness.
Neuropsychological deficits in psychotic versus nonpsychotic major depression and no mental illness.
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DOI：
10.1176/appi.ajp.157.7.1095
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发表时间：
2000-07
期刊：
影响因子：
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通讯作者：
A. Schatzberg;J. Posener;C. Debattista;B. Kalehzan;A. Rothschild;P. Shear
中科院分区：
文献类型：
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作者：
A. Schatzberg;J. Posener;C. Debattista;B. Kalehzan;A. Rothschild;P. Shear
目的：至少有三项研究表明，在非药物状态下研究的精神病性重度抑郁症患者与非精神病性重度抑郁症患者和健康对照者在若干神经心理表现指标上存在差异。本研究探讨了精神病性重度抑郁症患者、非精神病性重度抑郁症患者和健康对照者在无药物条件下认知功能的特异性损伤。方法对11例精神病性重性抑郁症患者、32例非精神病性重性抑郁症患者和23例正常对照者在无药物条件下进行神经心理测试。这三组在年龄、性别或教育水平上没有统计学差异。为了确保参与者具有最低程度的严重程度和内源性，所有患者都被要求在21项汉密尔顿抑郁评定量表中至少获得20分，在核心内基因组量表中至少获得7分，该量表使用汉密尔顿抑郁量表中的8项。结果精神病性重度抑郁症患者在注意力和反应抑制（通过Stroop颜色-单词亚量表评分测量）以及言语陈述性记忆（通过段落回忆测试测量）方面表现出比非精神病性重度抑郁症患者和/或对照组更大的损害。结论：这些数据表明精神病性重度抑郁症患者表现出被认为是由额叶和中颞叶介导的功能损害。
OBJECTIVE At least three studies have indicated that patients with psychotic major depression studied under non-drug-free conditions differ from patients with nonpsychotic major depression and healthy comparison subjects on several measures of neuropsychological performance. The current study explored specific impairments in cognitive function in subjects with psychotic major depression, subjects with nonpsychotic major depression, and healthy comparison subjects studied under drug-free conditions. METHOD A battery of neuropsychological tests was administered to 11 patients with psychotic major depression, 32 patients with nonpsychotic major depression, and 23 normal comparison subjects under drug-free conditions. The three groups did not differ statistically in age, sex, or level of education. To ensure that participants had minimal levels of severity and endogenicity, all patients were required to have a score of at least 20 on the 21-item Hamilton Depression Rating Scale and a score of at least 7 on the Core Endogenomorphic Scale, which uses eight items from the Hamilton depression scale. RESULTS Patients with psychotic major depression demonstrated significantly greater impairment than patients with nonpsychotic major depression and/or comparison subjects in attention and response inhibition (as measured by the Stroop color-word subscale score) as well as in verbal declarative memory (as measured by the Paragraph Recall Test). CONCLUSIONS These data indicate that patients with psychotic major depression demonstrate impairment in functions thought to be mediated by the frontal cortex and mediotemporal lobes.