Influence of interval between biopsy and surgery on prognosis of patients with early-stage oral squamous cell carcinoma: A preliminary study
Influence of interval between biopsy and surgery on prognosis of patients with early-stage oral squamous cell carcinoma: A preliminary study
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DOI：
10.1016/j.ajoms.2018.12.005
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发表时间：
2019-05-01
影响因子：
0.4
通讯作者：
Iino, Mitsuyoshi
中科院分区：
文献类型：
--
作者：
Hemmi, Tomoharu;Yusa, Kazuyuki;Iino, Mitsuyoshi
目的：最近的研究表明，术前干预，如拔牙，切开和刮除可能与口腔恶性肿瘤患者的预后不良。虽然活检是另一种术前干预措施，但其对口腔鳞状细胞癌（OSCC）患者预后的影响仍不清楚。材料与方法：对47例早期（T1或T2 N 0 M0）OSCC患者的临床资料进行回顾性分析。长间隔组的局部复发或迟发性颈淋巴结转移的发生率显著较高（p = 0.03）。局部或颈部衰竭患者的间隔时间（33.6天）明显长于稳定患者（21.9天; p < 0.01）。有、无复发转移组5年生存率分别为66.7%和90.6%（P < 0.05）。结论：延迟治疗可增加早期口腔鳞状细胞癌局部和颈部衰竭的发生率，从而恶化患者的预后。因此，建议活检后及时治疗，以优化结果。
Objective: Recent studies have suggested that preoperative interventions such as tooth extraction, incision and curettage may be associated with poor prognosis in patients with oral malignancies. Although biopsy is another preoperative intervention, its influence on the prognosis of patients with oral squamous cell carcinoma (OSCC) has remained unclear. We investigated the prognosis of stage I and II OSCC patients, with special reference to the influence of the interval between biopsy and surgery.Materials and methods: The cases of 47 patients diagnosed with primary early-stage (T1 or T2N0M0) OSCC were reviewed retrospectively.Results: Primary surgery was performed 21 days after biopsy for 30 patients. Incidence of local recurrence or delayed cervical lymph node metastasis was significantly higher among the long-interval group (p = 0.03). Patients with local or neck failure displayed a significantly longer interval (33.6 days) than patients who were stable (21.9 days; p < 0.01). Five-year survival rates in groups with and without recurrence or metastasis were 66.7% and 90.6%, respectively (p < 0.05).Conclusion: Treatment delay can worsen the prognosis of patients with early-stage OSCC by increasing the incidence of local and neck failure. Prompt treatment after biopsy is thus recommended to optimize the outcomes.