Detection of small numbers of monoclonal B lymphocytes in the blood of patients with lymphoma.
Detection of small numbers of monoclonal B lymphocytes in the blood of patients with lymphoma.
复制标题
淋巴瘤患者血液中少量单克隆 B 淋巴细胞的检测。
DOI：
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发表时间：
1979
影响因子：
158.5
通讯作者：
K. Ault
中科院分区：
文献类型：
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作者：
K. Ault
淋巴恶性肿瘤患者完全缓解和早期复发的定义因难以识别正常淋巴细胞群中存在少量恶性淋巴细胞而变得复杂。我们使用了一种基于细胞荧光检测淋巴细胞的方法来研究淋巴瘤患者的血液，该淋巴细胞具有同质量的一种轻链类型的表面免疫球蛋白。该测试能够可靠地检测正常血液中 10% 或更少的单克隆 B 淋巴细胞，并且在根据标准形态学技术被认为没有异常血细胞的患者中，显示出先前未怀疑的单克隆 B 淋巴细胞的高发生率（30% 至 40%）。估计此类细胞数量的能力可能有助于治疗计划并使完全缓解的概念更有意义。
The definition of complete remission and early relapse in patients with lymphoid malignancy is complicated by the difficulty of recognizing the presence of small numbers of malignant lymphocytes in a population of normal lymphocytes. We have used a method based on the cytofluorometric detection of lymphocytes having homogeneous amounts of surface immunoglobulin of one light-chain class to study blood from patients with lymphomas. The test is capable of reliably detecting 10 per cent or less of monoclonal B lymphocytes in normal blood, and it shows a high incidnece (30 to 40 per cent) of previously unsuspected monoclonal B lymphocytes in patients who were though to have no abnormal blood cells according to standard morphologic technics. The ability to estimate the number of such cells may facilitate the planning of therapy and make more meaningful the concept of complete remission.