Duration of diabetes and types of diabetes therapy in Japanese patients with type 2 diabetes: The Japan Diabetes Complication and its Prevention prospective study 3 (JDCP study 3).
Duration of diabetes and types of diabetes therapy in Japanese patients with type 2 diabetes: The Japan Diabetes Complication and its Prevention prospective study 3 (JDCP study 3).
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DOI：
10.1111/jdi.12550
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发表时间：
2017-03
影响因子：
3.2
通讯作者：
JDCP study group
中科院分区：
文献类型：
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作者：
Hayashino Y;Izumi K;Okamura S;Nishimura R;Origasa H;Tajima N;JDCP study group
在日本2型糖尿病患者的大型数据库中分析糖尿病病程与糖尿病治疗选择之间的相关性。我们使用了5，844例2型糖尿病患者的数据，以评估糖尿病病程与糖尿病治疗类型之间的相关性。采用Logistic回归模型分析糖尿病病程与糖尿病治疗选择的关系，并采用限制性三次样条曲线表示糖尿病病程与糖尿病治疗选择的关系。总体而言，患者的临床特征为女性，39.9%;平均年龄61.4岁;糖尿病中位病程9年;平均糖化血红蛋白7.4%（57.0 mmol/mol）;平均体重指数24.5 kg/m2。与糖尿病病程的第一个四分位数相比，任何降糖治疗的多变量校正优势（口服降糖药或胰岛素）的第二、第三和第四四个四分位数分别为2.17（95%置信区间[CI] 1.68-2.80; 3.39，95% CI 2.53-4.54; 4.99，95% CI 3.64-6.84）（趋势P <0.001），调整可能的混杂因素后，这些相关性减弱。此外，胰岛素治疗组分别为1.48（95% CI 1.20-1.84; 2.16，95% CI 1.77-2.64; 4.94，95% CI 4.04-6.04）（趋势P <0.001）。限制性三次样条曲线分析的示意图显示，糖尿病病程较长与胰岛素治疗的可能性呈线性相关。获得的数据表明，糖尿病持续时间较长，需要向2型糖尿病患者引入复杂的糖尿病药物方案。
To analyze the association between the duration of diabetes and selection of diabetes therapy in a large database of Japanese patients with type 2 diabetes. We used the data of 5,844 patients with type 2 diabetes to evaluate the association between the duration of diabetes and types of diabetes therapy. The logistic regression model was used to analyze the association between duration of diabetes and selection of diabetes therapy, and restricted cubic spline curves were used to represent the schematic association. Overall, clinical characteristics of the patients were women, 39.9%; mean age, 61.4 years; median duration of diabetes, 9 years; mean glycated hemoglobin, 7.4% (57.0 mmol/mol); and mean body mass index, 24.5 kg/m2. Compared with the first quartile of diabetes duration, the multivariable‐adjusted odds of any antidiabetic therapy (oral hypoglycemic agents or insulin) for the second, third and fourth quartiles were 2.17 (95% confidence interval [CI] 1.68–2.80; 3.39, 95% CI 2.53–4.54; 4.99, 95% CI 3.64–6.84), respectively (P for trend <0.001), and these associations were attenuated after adjusting possible confounders. Furthermore, those of insulin therapy were 1.48 (95% CI 1.20–1.84; 2.16, 95% CI 1.77–2.64; 4.94, 95% CI 4.04–6.04), respectively (P for trend <0.001). Schematic representation of restricted cubic spline curves analysis showed that a longer duration of diabetes was linearly associated with the odds of insulin therapy. Obtained data showed that a longer duration of diabetes required complex diabetes drug regimens to be introduced to patients with type 2 diabetes.