Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas
Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas
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DOI：
10.1002/ana.10679
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发表时间：
2003-09-01
影响因子：
11.2
通讯作者：
Weller, M
中科院分区：
文献类型：
--
作者：
Platten, M;Kretz, A;Weller, M
巨噬细胞被认为是抗肿瘤免疫的第一道防线。然而，尽管有小胶质细胞浸润，恶性胶质瘤是一种僵硬的高侵袭性肿瘤。我们在此发现单核细胞化学引诱蛋白-1 （MCP-1）是胶质瘤浸润性小胶质细胞的关键化学引诱剂。mcp -1转染的大鼠CNS-1胶质瘤被小胶质细胞大量浸润。尽管MCP-1在体外没有促进CNS-1细胞的生长，但脑内转染CNS-1的肿瘤比对照转染的肿瘤生长得更有攻击性。这提供了MCP-1向胶质瘤募集小胶质细胞并促进其在体内生长的第一个功能证据。小胶质细胞可能支持而不是抑制胶质瘤的生长。
Macrophages are thought to represent a first line of defense in anti-tumor immunity. Despite infiltration by microglial cells, however, malignant gliomas are stiff highly aggressive tumors. We here identify monocyte chemoattractant protein-1 (MCP-1) as a critical chemoattractant for glioma-infiltrating microglial cells. MCP-1-transfected rat CNS-1 gliomas were massively infiltrated by microglial cells. Whereas MCP-1 did not promote the growth of CNS-1 cells in vitro, intracerebral CNS-1-transfected tumors grew more aggressively than control-transfected tumors. This provides the first functional evidence that MCP-1 recruits microglial cells to gliomas and promotes their growth in vivo. Microglial cells may support rather than suppress glioma growth.