Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy.
Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy.
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DOI：
10.3390/ijms19020623
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发表时间：
2018-02-22
影响因子：
5.6
通讯作者：
Wojtkiewicz J
中科院分区：
文献类型：
--
作者：
Krajewska-Włodarczyk M;Owczarczyk-Saczonek A;Placek W;Osowski A;Wojtkiewicz J
关节软骨在衰老过程中的变化是人体自然变化的一个阶段。老年是骨关节炎的主要危险因素，但这种疾病并不一定是衰老的必然后果。软骨细胞特别容易发生与年龄相关的变化。在老化过程中发生的关节软骨的变化包括软骨细胞获得衰老相关的分泌表型、软骨细胞对生长因子的敏感性降低、活性氧的慢性产生的破坏性作用和糖化终产物的积累。所有这些因素都会影响关节软骨的力学性能。更好地了解关节软骨老化过程中的潜在机制可能有助于创造新的治疗方法，旨在减缓或抑制与年龄相关的关节软骨变化。本文介绍了软骨细胞老化的原因和后果，以及关节软骨老化性病变再生的生物治疗前景。
Changes in articular cartilage during the aging process are a stage of natural changes in the human body. Old age is the major risk factor for osteoarthritis but the disease does not have to be an inevitable consequence of aging. Chondrocytes are particularly prone to developing age-related changes. Changes in articular cartilage that take place in the course of aging include the acquisition of the senescence-associated secretory phenotype by chondrocytes, a decrease in the sensitivity of chondrocytes to growth factors, a destructive effect of chronic production of reactive oxygen species and the accumulation of the glycation end products. All of these factors affect the mechanical properties of articular cartilage. A better understanding of the underlying mechanisms in the process of articular cartilage aging may help to create new therapies aimed at slowing or inhibiting age-related modifications of articular cartilage. This paper presents the causes and consequences of cellular aging of chondrocytes and the biological therapeutic outlook for the regeneration of age-related changes of articular cartilage.
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影响因子：
5.6
作者：
Baldari S;Di Rocco G;Piccoli M;Pozzobon M;Muraca M;Toietta G
通讯作者：
Toietta G
影响因子：
7.8
作者：
Bernardes de Jesus B;Schneeberger K;Vera E;Tejera A;Harley CB;Blasco MA
通讯作者：
Blasco MA
影响因子：
--
作者：
Aurich, M;Poole, AR;Cole, AA
通讯作者：
Cole, AA
影响因子：
3.7
作者：
Brandl, Anita;Meyer, Matthias;Angele, Peter
通讯作者：
Angele, Peter
影响因子：
4.1
作者：
Bian, Liming;Zhai, David Y.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.