Combination chemotherapy with adriamycin and cis‐diamminedichloroplatinum in patients with neoplastic diseases
Combination chemotherapy with adriamycin and cis‐diamminedichloroplatinum in patients with neoplastic diseases
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阿霉素与顺式二氯铂联合化疗治疗肿瘤疾病
DOI：
10.1002/1097-0142(197607)38:1
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发表时间：
1976
期刊：
影响因子：
6.2
通讯作者：
J. Holland
中科院分区：
文献类型：
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作者：
S. Vogl;T. Ohnuma;M. Perloff;J. Holland
48 名患有各种晚期实体瘤的患者接受阿霉素 50 mg/m2 和顺式二氯二氨铂 50 mg/m2 的联合治疗，每 2 至 4 周一次。 15 名患者的可测量肿瘤消退超过 50%：其中 6 名患者患有肺癌；一、乳腺癌；一、卵巢；一、子宫颈；一、前列腺；一、睾丸；一、上颌窦；一名是唾液腺，另外一名是化学感受器瘤患者，另一名是原发灶不明的腺癌患者。反应持续 1 至 18 个月，中位数为 6 个月。另外六名患者，包括两名肺腺癌患者、三名宫颈癌患者和一名胚胎细胞睾丸癌患者得到改善（肿瘤消退 25-50%）。遇到的毒性包括骨髓抑制、氮质血症、脱发、恶心、呕吐和口腔炎。严重的血液毒性仅发生在骨髓功能受损或并发活动性肝炎的患者中。似乎并没有发生该组合引起的毒性的主要增强。
Forty‐eight patients with a variety of advanced solid tumors were treated with a combination of adriamycin 50 mg/m2, and cis‐diamminedichloroplatinum 50 mg/m2, every 2 to 4 weeks. Fifteen patients responded with a greater than 50% regression of measurable tumor: six with lung cancer; one, carcinoma of the breast; one, ovary; one, cervix; one, prostate; one, testis; one, maxillary sinus; and one, salivary gland, plus one patient with chemodectoma and one with adenocarcinoma of unknown primary. Responses lasted 1 to 18 months, with a median of 6 months. An additional six patients, including two with adenocarcinoma of the lung, three with carcinoma of the cervix, and one with embryonal cell testicular carcinoma improved (25–50% regression of the tumor). Toxicity encountered included myelosuppression, azotemia, alopecia, nausea, vomiting, and stomatitis. Severe hematologic toxicity occurred only in those with compromised marrow function or with concurrent active hepatitis. Major potentiation of toxicity by the combination does not appear to have occurred.