The role of sphingolipids in endothelial barrier function.
The role of sphingolipids in endothelial barrier function.
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DOI：
10.1515/hsz-2014-0305
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发表时间：
2015-06
影响因子：
3.7
通讯作者：
Pritts TA
中科院分区：
文献类型：
--
作者：
Jernigan PL;Makley AT;Hoehn RS;Edwards MJ;Pritts TA
鞘脂是一个普遍存在的必需脂质家族，其在许多生理和病理过程中作为生物活性介质的作用越来越被人们所理解。两种特殊的鞘脂，1-磷酸鞘氨醇和神经酰胺及其代谢物直接和间接与内皮细胞相互作用，调节血管通透性。 1-磷酸鞘氨醇通常会增强内皮完整性，而神经酰胺往往会促进血管渗漏，两者之间的紧密平衡对于维持正常的生理功能是必要的。鞘脂调节内皮屏障功能的机制很复杂，并且通过多种不同的途径发生，并且这些途径的破坏或不平衡与许多特定的疾病过程有关。随着对鞘脂生物学、内皮功能以及两者之间相互作用的了解的加深，治疗干预的几个目标已经出现，并且该领域有进一步发展的巨大潜力。
Sphingolipids are a ubiquitous family of essential lipids with an increasingly understood role as biologically active mediators in numerous physiologic and pathologic processes. Two particular sphingolipid species, sphingosine-1-phosphate and ceramide, and their metabolites interact both directly and indirectly with endothelial cells to regulate vascular permeability. Sphingosine-1-phosphate generally augments endothelial integrity while ceramide tends to promote vascular leak, and a tight balance between the two is necessary to maintain normal physiologic function. The mechanisms by which sphingolipids regulate endothelial barrier function are complex and occur through multiple different pathways, and disruptions or imbalances in these pathways have been implicated in a number of specific disease processes. With improved understanding of sphingolipid biology, endothelial function, and the interactions between the two, several targets for therapeutic intervention have emerged and there is immense potential for further advancement in this field.