Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development
Phlenumdines D and E, new Lycopodium alkaloids from Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development
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Phlenumdines D 和 E，来自 Phlegmariurus nummulariifolius 的新石松生物碱，及其对肿瘤发育过程中巨噬细胞分化的调节作用
DOI：
10.1016/j.phytol.2018.11.010
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发表时间：
2018
影响因子：
1.7
通讯作者：
Ishiuchia K.
中科院分区：
文献类型：
--
作者：
Nakayama W;Fujiwara Y;Kosuge Y;Monthakantirat O;Fujikawa K;Watthana S;Kitanaka S;Makino T;Ishiuchia K.
从云芝中分离得到两个新的石松二碱类化合物D(1)和E(2)和10个已知化合物(3−12)，其结构经波谱分析确证。分别用化学转化法和改进的Mosher法确定了1和2的绝对构型。连翘碱E(2)、A(8)、石杉碱甲(12)和12-表-石油醚-N-氧化物(14)对白细胞介素10(IL-10)诱导的人单核细胞来源巨噬细胞(HMDM)的M2表型标志物CD163的表达有抑制作用。
Two newLycopodiumalkaloids, phlenumdines D (1) and E (2), have been isolated from the club mossPhlegmariurus nummulariifolius(Blume) Ching along with ten known compounds (3−12), and the structures were elucidated by spectroscopic analyses. The absolute configurations of1and2were established by chemical conversion and modified Mosher’s method, respectively. Phlenumdines E (2), A (8), hupermine A (12), and 12-epi-lycopodine-N-oxide (14) exhibited an inhibitory effect on interleukin 10 (IL-10)-induced expression of CD163, a M2 phenotype marker, in human monocyte-derived macrophages (HMDMs).