Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer
Targeted delivery of daunorubicin to T-cell acute lymphoblastic leukemia by aptamer
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DOI：
10.3109/10611860903434050
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发表时间：
2010-05-01
影响因子：
4.5
通讯作者：
Behravan, Javad
中科院分区：
文献类型：
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作者：
Taghdisi, Seyed Mohammad;Abnous, Khalil;Behravan, Javad
柔红霉素在白血病治疗中的应用因其心脏毒性等副作用而受到限制。化疗药物的特异性递送是减少化疗药物副作用的重要因素。在这项研究中，sgc8是蛋白酪氨酸激酶-7 （PTK7）的适配体，用于将柔红霉素特异性递送到Molt-4细胞（PTK7）
Application of daunorubicin in treatment of leukemia has been limited for its side effects like cardiotoxicity. Specific delivery of chemotherapy drugs is an important factor in decreasing their side effects. In this study, sgc8, an aptamer for protein tyrosine kinase-7 (PTK7), was used for specific delivery of daunorubicin to Molt-4 cells (PTK7