TNF-376A marks susceptibility to MS in the Spanish population -: A replication study
TNF-376A marks susceptibility to MS in the Spanish population -: A replication study
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DOI：
10.1212/01.wnl.0000113722.93895.8b
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发表时间：
2004-03-09
期刊：
影响因子：
9.9
通讯作者：
de la Concha, EG
中科院分区：
文献类型：
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作者：
Martínez, A;Rubio, A;de la Concha, EG
本研究旨在重新评估TNF-376 A启动子多态性与多发性硬化症易感性之间的关联，该关联在西班牙人群中发现，但在其他人群中未发现。使用患者（n = 241）和对照受试者（n = 288）的新数据集，证实了相关性（p = 0.018）。作者的数据表明，这种关联是西班牙白色（或相关）人群特有的，或者，由于携带TNF-376 A等位基因的扩展、保守单倍型的频率较高，因此只有在其人群中进行的研究才具有足够的统计效力。
This study was designed as a reappraisal of the association between the TNF-376A promoter polymorphism and susceptibility to multiple sclerosis found in the Spanish population but not in other populations. With a new dataset of patients (n = 241) and control subjects ( n = 288), the association was confirmed ( p = 0.018). The authors' data suggest that this association is specific of the Spanish white ( or related) population or, alternatively, that only studies in their population have the adequate statistical power because of the higher frequency of an extended, conserved haplotype carrying the TNF-376A allele.