Osmoregulatory control of renal sodium excretion after sodium loading in humans
Osmoregulatory control of renal sodium excretion after sodium loading in humans
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DOI：
10.1152/ajpregu.1998.275.6.r1833
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发表时间：
1998-12-01
影响因子：
2.8
通讯作者：
Bie, P
中科院分区：
文献类型：
--
作者：
Andersen, LJ;Norsk, P;Bie, P
肾脏钠处理受血浆钠浓度变化控制的假设在坐着的志愿者中进行了测试。在连续摄入75 (lna（+）或300 mmol/天（HiNa(+)）的4天后，给予标准盐负荷（3.08 mmol/kg体重超过120分钟）0.9%生理盐水（Isot）或5%生理盐水（Hypr）。无论饮食如何，Hypr均可使血浆钠增加4 mmol/l，但血浆容量和中心静脉压的增加明显低于Isot。在LoNa（+）作用后，Hypr诱导的钠排泄量增加幅度小于Isot （48 +/- 8 vs 110 +/- 17 mu mol/min）。然而，在HiNa（+）后，相应的钠量是相同的（135 +/- 33 vs 139 +/- 39 mu mol/min），尽管中心静脉压升高之间存在显著差异。血浆ANG II浓度降低23-52%与钠排泄呈负相关。平均动脉压、血浆催产素和心房利钠肽浓度以及尿中内皮素-1和尿舒张素排泄率保持不变。结果表明，当盐摄入量高时，血浆钠的增加可能有助于盐负荷的钠尿，支持了正常坐姿中渗透刺激的钠尿依赖于钠平衡的假设。
The hypothesis that renal sodium handling is controlled by changes in plasma sodium concentration was tested in seated volunteers. A standard salt load (3.08 mmol/kg body wt over 120 min) was administered as 0.9% saline (Isot) or as 5% saline (Hypr) after 4 days of constant sodium intake of 75 (LoNa(+)) or 300 mmol/day (HiNa(+)). Hypr increased plasma sodium by similar to 4 mmol/l but increased plasma volume and central venous pressure significantly less than Isot irrespective of diet. After LoNa(+), Hypr induced a smaller increase in sodium excretion than Isot (48 +/- 8 vs. 110 +/- 17 mu mol/min). However, after HiNa(+) the corresponding natriureses were identical (135 +/- 33 vs. 139 +/- 39 mu mol/min), despite significant difference between the increases in central venous pressure. Decreases in plasma ANG II concentrations of 23-52% were inversely related to sodium excretion. Mean arterial pressure, plasma oxytocin and atrial natriuretic peptide concentrations, and urinary excretion rates of endothelin-1 and urodilatin remained unchanged. The results indicate that an increase in plasma sodium may contribute to the natriuresis of salt loading when salt intake is high, supporting the hypothesis that osmostimulated natriuresis is dependent on sodium balance in normal seated humans.