Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis
Serum CXCL9 and CCL17 as biomarkers of declining pulmonary function in chronic bird-related hypersensitivity pneumonitis
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DOI：
10.1371/journal.pone.0220462
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发表时间：
2019-08-01
期刊：
影响因子：
3.7
通讯作者：
Miyazaki, Yasunari
中科院分区：
文献类型：
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作者：
Nukui, Yoshihisa;Yamana, Takashi;Miyazaki, Yasunari
慢性过敏性肺炎(HP)合并纤维化的临床过程与特发性肺纤维化(IPF)相似。目前的研究有望在临床环境中确定有效预测肺功能恶化的生物标志物。我们小组分析了慢性鸟类相关性幽门螺杆菌患者的以下参数之间的关系：患者特征、血清标志物、肺功能、HRCT表现、BALF特征和肺功能恶化。我们还分析了血清CXCL9、CCL17和Krebs von den lugen 6(KL-6)水平作为血清标志物。首次入院后6个月肺活量(VC)下降超过5%的患者被归类为“下降组”；其他患者被归类为“稳定组”。下降组血清CCL17水平和BALF巨噬细胞百分率明显高于稳定组。血清CXCL9和CCL17水平是VC下降相关因素的多因素Logistic回归分析中的重要变量。在聚类分析中，趋化因子谱结合较低的血清CXCL9和较高的血清CCL17的患者显示出显著更大的VC下降。血清CCL17水平升高和CXCL9水平降低是慢性禽类HP患者肺功能恶化的重要预测因子。
The clinical course of chronic hypersensitivity pneumonitis (HP) with fibrosis is similar to that of idiopathic pulmonary fibrosis (IPF). Current research is expected to identify biomarkers effective in predicting the deterioration of lung function in a clinical setting. Our group analyzed the relationships between the following parameters in chronic bird-related HP: patient characteristics, serum markers, lung function, HRCT findings, BALF profiles, and the worsening of lung function. We also analyzed serum levels of CXCL9, CCL17, and Krebs von den Lungen 6 (KL-6) as serum markers. Patients showing declines in vital capacity (VC) of over 5% at 6 months after first admission were categorized as the "decline group"; the others were categorized as the "stable group." The serum level of CCL17 and the percentage of BALF macrophages were significantly higher in the decline group compared to the stable group. Serum levels of CXCL9 and CCL17 were significant variables in a multivariate logistic regression analysis of factors associated with VC decline. Patients with a chemokine profile combining lower serum CXCL9 and higher serum CCL17 exhibited significantly larger VC decline in a cluster analysis. Higher serum CCL17 and lower serum CXCL9 were important predictors of worsening lung function in patients with chronic bird-related HP.