Correlation of inhaled nitric-oxide induced reduction of pulmonary artery pressure and vascular changes
Correlation of inhaled nitric-oxide induced reduction of pulmonary artery pressure and vascular changes
复制标题
吸入一氧化氮引起的肺动脉压降低与血管变化的相关性
DOI：
10.1183/09031936.02.00249302
复制
发表时间：
2002
影响因子：
24.3
通讯作者：
K. Maruyama
中科院分区：
文献类型：
--
作者：
B. Jiang;J. Maruyama;A. Yokochi;H. Amano;Y. Mitani;K. Maruyama
本研究的目的是确定在低剂量一氧化氮（NO）吸入过程中高血压肺血管重构和平均肺动脉压（mPAP）的变化之间的关系。大鼠慢性低压缺氧（空气压力50.5kPa（380 mmHg），氧浓度10%，持续5-29天），诱发慢性肺动脉高压（PH），肺血管结构改变。 慢性低氧暴露后，大鼠有一个留置肺动脉导管插入和mPAP与NO的变化与肺血管变化的形态计量学分析相关。所有浓度的吸入NO（百万分之0.1-2.0）降低mPAP，PH大鼠的mPAP较基线降低的百分比相似，而对照组大鼠没有观察到变化。在PH大鼠吸入NO期间，mPAP降低的绝对值（但不是mPAP降低的百分比）与基线mPAP、肺泡壁水平和肺泡管水平的肌化动脉百分比以及肌化动脉的中壁厚度百分比显著相关。在慢性缺氧性肺动脉高压模型中，肺血管重构的严重程度并没有改变肺动脉对一氧化氮的反应性，并且可能部分地决定了一氧化氮诱导的平均肺动脉压绝对降低的幅度。
The purpose of the present study was to determine the relationship between hypertensive pulmonary vascular remodelling and the changes in mean pulmonary artery pressure (mPAP) during low-dose nitric oxide (NO) inhalation. Rats were exposed to chronic hypobaric hypoxia (air at 50.5 kPa (380 mmHg), 10% oxygen, for 5–29 days) to induce chronic pulmonary hypertension (PH) with pulmonary vascular structural changes. After the chronic hypoxic exposure, the rats had an indwelling pulmonary artery catheter inserted and changes in mPAP with NO were correlated to morphometrical analysis of pulmonary vascular changes. All concentrations of inhaled NO (0.1–2.0 parts per million) reduced mPAP with a similar per cent reduction from baseline mPAP in PH rats, while no changes were observed in control rats. During NO inhalation in PH rats, the absolute value of the decrease in mPAP, but not per cent reduction in mPAP, significantly correlated with baseline mPAP, the percentage of muscularised arteries at the alveolar wall level and at the alveolar duct level, and the per cent medial wall thickness of muscularised arteries. In the chronic hypoxic pulmonary hypertension model, the severity of pulmonary vascular remodelling did not alter the reactivity of the pulmonary arteries to nitric oxide and might, in part, determine the magnitude of nitric-oxide induced absolute reduction in mean pulmonary artery pressure.
缺氧引起的肺动脉高压中的肺动脉平滑肌收缩力。
DOI：
10.1152/jappl.1994.77.1.406
发表时间：
1994
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Griffith,SL;Rhoades,RA;Packer,CS
通讯作者：
Packer,CS
影响因子：
3.3
作者：
E. Orton;J. Reeves;K. Stenmark
通讯作者：
E. Orton;J. Reeves;K. Stenmark