Investigation of relation between use of oral contraceptives and thromboembolic disease.
Investigation of relation between use of oral contraceptives and thromboembolic disease.
复制标题
口服避孕药的使用与血栓栓塞性疾病之间关系的调查。
作者：
G. M. Barendt;M. L. Blair;B. Bryson;R. J.;Clyne;E. M. Cruickshank;M. Dales;E. N. Davey;E. C. Evans;M. Evans;E. S. Hallifax;C. M.;Halstead;A. H. Holmes;G. A. Z. Holti;R. James;M. McAlley;S. F. Marwood;I. C. A. Moyse;A. Pearson;K. M. Pearson;Z. C. Randall;B. Richardson;W. Sharrard;A. Simpson;G. Thyne;J. Tisdall;S. Toogood;M. Vessey;R. Doll
为确定口服避孕药的使用与血栓栓塞性疾病的关系，对伦敦附近19家医院出院的58名年龄在16岁至40岁的已婚妇女进行了访谈，这些妇女被诊断为血栓栓塞性疾病(ICD 463-466)，但没有先兆。116名未受这些疾病影响的已婚对照组在住院日期、年龄和产次方面进行了匹配。对照组的不同之处在于既往血栓栓塞症的发生率较低，体重较轻，吸烟较少。在58名受试者中，26人(45%)在病前一个月内服用避孕药，而在116名对照组中，10人(9%)正在服用避孕药，相对危险度为9。在9名脑血栓患者中，有5人在服用避孕药。在13名患有冠状动脉血栓的女性中，没有一人是吸毒者。
To determine the relationship between use of oral contraceptives and thromboembolic disease 58 married women aged 16 to 40 years discharged from 19 hospitals near London with diagnosis of thromboembolic diseases (ICD 463-466) without predispoition were interviewed. 116 married controls unaffected by these diseases were matched by hospital admission date age and parity. The controls differed in lower incidence of previous thromboembolism lower weight less heavy smoking. Of 58 affected 26 (45%) were using pills within the month prior to illness and among 116 controls 10 (9%) were using pills yielding a relative risk of 9. In a small sample of 9 patients with cerebral thrombosis 5 were using the pill. Of 13 women with coronary thrombosis none were users.