Resistance of Extrathymic T Cells to Stress and the Role of Endogenous Glucocorticoids in Stress Associated Immuno Suppression
Resistance of Extrathymic T Cells to Stress and the Role of Endogenous Glucocorticoids in Stress Associated Immuno Suppression
复制标题
胸腺外 T 细胞对应激的抵抗力以及内源性糖皮质激素在应激相关免疫抑制中的作用
DOI：
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发表时间：
2000
影响因子：
3.7
通讯作者：
Abo
中科院分区：
文献类型：
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作者：
Shimizu;Kawamura;Miyaji;Oya;Bannai;Yamamoto;Weerasinghe;Halder;Watanabe;Hatakeyama;Abo
当小鼠暴露于约束应激12或24小时时，包括肝脏和胸腺在内的所有免疫系统器官都引起严重的淋巴细胞减少。然而，在肾上腺切除的小鼠中，这种反应完全不存在。表型表征显示，CD4+表型的白细胞介素（IL）‐2Rβ+CD3int细胞（即胸腺外T细胞）和肝脏中CD3int细胞的NK1.1+亚群（即NKT细胞）以及胸腺中成熟的常规T细胞对这种应激具有抗性。肾上腺切除小鼠，应激前各脏器淋巴细胞亚群分布无明显变化。有趣的是，在这些肾上腺切除小鼠应激后，肝脏和脾脏的淋巴细胞数量和肝脏中NKT细胞的比例反而增加。因此，内源性类固醇激素在应激后免疫抑制状态的诱导中起重要作用。在应激相关的细胞因子中，肾上腺切除小鼠的肿瘤坏死因子（TNF）‐α的分泌被完全抑制，而IL‐6的分泌被部分抑制。这些结果表明，内源性类固醇激素对诱导应激相关的免疫抑制很重要，并且NKT细胞对应激具有抗性，即对暴露于内源性类固醇激素具有抗性。
When mice were exposed to restraint stress for 12 or 24 h, severe lymphopenia was induced in all immune system organs, including the liver and the thymus. However, in adrenalectomized mice, this response was completely absent. Phenotypic characterization revealed that interleukin (IL)‐2Rβ+CD3int cells (i.e. extrathymic T cells) with CD4+ phenotype and the NK1.1+ subset of CD3int cells (i.e. NKT cells) in the liver as well as the mature conventional T cells in the thymus were resistant to such stress. In adrenalectomized mice, there was no significant change in the distribution of lymphocyte subsets in all tested organs before stress. Interestingly, the number of lymphocytes in the liver and spleen and the proportion of NKT cells in the liver rather increased after stress in these adrenalectomized mice. Therefore, endogenous steroid hormones were indicated to be important in the induction of immunosuppressive states after stress. Among stress associated cytokines, the secretion of tumour necrosis factor (TNF)‐α was completely suppressed while that of IL‐6 was partially suppressed in adrenalectomized mice. These results suggest that endogenous steroid hormones are important for the induction of the stress associated immunosuppression and that NKT cells are resistant to stress, namely, resistant to exposure to endogenous steroid hormones.
人类 T 细胞发育过程中 bcl-2 原癌基因的表达。
DOI：
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发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gratiot-Deans,J;Ding,L;Turka,LA;Nunez,G
通讯作者：
Nunez,G
DOI：
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发表时间：
1995
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Bix,M;Locksley,RM
通讯作者：
Locksley,RM