Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
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DOI：
10.1038/82924
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发表时间：
2001-01-01
影响因子：
25
通讯作者：
Craig, AD
中科院分区：
文献类型：
--
作者：
Andrew, D;Craig, AD
我们发现一类脊髓丘脑束（STT）的Ⅰ层神经元可被离子电渗组胺选择性地激活。这类神经元的反应与该刺激在人类身上引发的单纯瘙痒感相似，并且与具有相似选择性的外周C纤维的反应相匹配。这些神经元具有不同的中枢传导速度和丘脑投射，这表明它们构成了STT神经元的一个独特亚群。这些发现可以解释为什么外侧脊髓丘脑束的损伤会同时破坏瘙痒以及疼痛和温度感觉。我们的研究结果提供了有力的证据，表明瘙痒由外周和中枢的特定神经元所介导。
We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral STT disrupts itch along with pain and temperature sensations. Our findings provide strong evidence that itch is subserved by specific neural elements both peripherally and centrally.