Prognostic impact of TID in regadenoson MPI: Some patients and certain events.
Prognostic impact of TID in regadenoson MPI: Some patients and certain events.
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TID 对 regadenoson MPI 的预后影响：一些患者和某些事件。
DOI：
10.1007/s12350-015-0299-9
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Bourque,JamiesonM
中科院分区：
文献类型：
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作者：
Löffler,AdriánI;Bourque,JamiesonM
与运动应激心电图相比，单光子发射计算机断层扫描（SPECT）心肌灌注成像（MPI）具有增加的诊断和预后价值，而短暂性脑缺血扩张（TID）的评估是其检测高风险患者能力的关键因素。在运动MPI患者中，TID的诊断和预后作用已被广泛评估。然而，在美国每年进行的* 1000万MPI研究中，约有50%进行了药理学MPI， 3由于患者耐受性提高、安全性和易于给药，大多数使用瑞腺苷松治疗血管扩张剂应激。鉴于该检测的高流行率，TID在该人群中的意义非常重要。TID在regadenoson MPI中的诊断作用先前已被评估，但预后影响尚未确定。在本期杂志中，Lester等人首次分析了TID与regadenoson MPI的预后效用。在这项执行良好的研究中，Lester等人评估了在平均29个月的887例患者中，异常TID比率为1.33对心源性死亡、心肌梗死（MI）或晚期冠状动脉重建术（CR）复合的预后影响；75%的队列灌注模式异常。TID在
Single-photon emission-computed tomographic (SPECT) myocardial perfusion imaging (MPI) has incremental diagnostic and prognostic value over exercise stress electrocardiography, and the assessment of transient ischemic dilation (TID) is a key contributor to its ability to detect higher risk patients. The diagnostic and prognostic role of TID has been evaluated extensively in those undergoing exercise MPI. 1, 2 However, approximately 50% of the* 10 million MPI studies performed annually in the US undergo pharmacologic MPI, 3 the majority receiving regadenoson for vasodilator stress due to its improved tolerability by patients, safety profile, and ease of administration. 4 Given the high prevalence of this testing, the significance of TID in this population is of high importance. The diagnostic role of TID in regadenoson MPI has been assessed previously, but the prognostic impact has not determined.In this issue of the Journal, Lester et al provide the first analysis of the prognostic utility of TID with regadenoson MPI. In this well-performed study, Lester et al assessed the prognostic impact of an abnormal TID ratio of 1.33 on a composite of cardiac death, myocardial infarction (MI), or late coronary revascularization (CR) in 887 patients over a mean of 29 months; 75% of the cohort had an abnormal perfusion pattern. TID was