SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus
SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus
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DOI：
10.1038/sj.onc.1207341
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发表时间：
2004-03-18
期刊：
影响因子：
8
通讯作者：
Butel, JS
中科院分区：
文献类型：
--
作者：
Arrington, AS;Moore, MS;Butel, JS
猿猴病毒40 （SV40）是一种已知可在实验动物中诱发癌症的DNA肿瘤病毒。有许多报道称，在人类恶性肿瘤（包括脑癌）中检测到SV40 DNA和/或蛋白质，这些肿瘤与动物中SV40诱导的肿瘤类型相同。然而，已知的病毒暴露尚未与特定个体的癌症发展直接相关。本文描述了一名实验室研究人员脑膜瘤中SV40序列的检测，该研究人员可能直接暴露于SV40，随后发展为肿瘤病毒DNA序列阳性，与实验室来源的病毒DNA序列难以区分。这个病例表明病毒暴露与肿瘤发展之间存在联系。
Simian virus 40 ( SV40) is a DNA tumor virus known to induce cancers in laboratory animals. There are numerous reports of the detection of SV40 DNA and/ or proteins in human malignancies of the same types as those induced by SV40 in animals, including brain cancers. However, known exposure to the virus has not yet been linked directly to cancer development in a specific individual. Here we describe the detection of SV40 sequences in the meningioma of a laboratory researcher who had a probable direct exposure to SV40 and subsequently developed a tumor positive for viral DNA sequences indistinguishable from those of the laboratory source. This case suggests a link between viral exposure and tumor development.