HYALURONIC ACID AND HYALURONIDASE IN THE AQUEOUS HUMOUR AND THE ANGLE OF THE ANTERIOR CHAMBER
HYALURONIC ACID AND HYALURONIDASE IN THE AQUEOUS HUMOUR AND THE ANGLE OF THE ANTERIOR CHAMBER
复制标题
DOI：
10.1111/j.1748-1716.1955.tb01208.x
复制
发表时间：
1955-01-01
期刊：
影响因子：
--
通讯作者：
WOODIN, AM
中科院分区：
文献类型：
--
作者：
BARANY, EH;WOODIN, AM
本文对影响前房角流体阻力的一些重要因素进行了研究。已经研究了房水中可能出现的影响耐药性的化学试剂，并在透明质酸酶的帮助下研究了屏障的性质。有以下主要結果: 1.在牛房水中未检测到透明质酸酶，2.房水中含有透明质酸，可通过添加透明质酸酶进行水解。房水中含有可扩散的热稳定成分，可降低滑液中透明质酸-蛋白质复合物的粘度。二乙基二硫代氨基甲酸盐可抑制该成分的作用。4.在诱导机械性创伤引起的抵抗力逐渐下降后，在房水中未观察到透明质酸解聚力增加。5.机械性创伤有时似乎通过即刻的物理紊乱作用于角度，随后是缓慢的温度依赖性阶段。后者不受二乙基二硫代氨基甲酸盐的抑制。少量睾丸透明质酸酶引起的快速初始抵抗力下降也可由葡萄球菌透明质酸酶诱导。7.在用缓冲液灌注角8小时后，电阻持续降低。以房水作为灌注液，电阻稳定约100分钟，然后降低。当用水灌注时，角中的透明质酸酶敏感成分在几百分钟内不会消失。8.除了在低浓度下的即时作用外，在高浓度下的透明质酸酶还诱导角的阻力进一步缓慢降低。
A study has been made of some factors which might be of importance for the hydrodynamic resistance of the angle of the anterior chamber. The possible occurrence in the aqueous humour of chemical agents affecting the resistance has been investigated and the nature of the barrier studied with the aid of hyaluronidase. The main results are:1. No hyaluronidase could be detected in cattle aqueous humour,2. Aqueous humour contains hyaluronic acid capable of being hydrolysed by added hyaluronidase.3. Aqueous humour has a diffusable thermo‐stable component which reduces the viscosity of the hyaluronic acid‐protein complex from synovial fluid. The action of this component is inhibited by diethyldithiocarbamate.4. No increase in hyaluronic acid‐depolymerising power is observable in aqueous humour after induction of the gradual break down of resistance caused by mechanical trauma.5. Mechanical trauma sometimes seems to act on the angle through an immediate physical derangement followed by a slower, temperature‐dependent phase. This latter is not inhibited by diethyldithiocarbamate.6. The fast initial resistance drop caused by small amounts of testicular hyaluronidase can also be induced by staphylococcal hyaluronidase.7. On perfusing the angle for 8 hours with buffer, the resistance decreases continuously. With aqueous humour as perfusate the resistance is stable for about 100 minutes and then decreases. The hyaluronidase‐sensitive component in the angle does not disappear for several hundred minutes when perfused with aqueous.8. In addition to its immediate action in low concentrations, hyaluronidase in high concentrations induces a further slow decrease in resistance of the angle.