Honeybees and tetracycline resistance.
Honeybees and tetracycline resistance.
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DOI：
10.1128/mbio.00045-13
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发表时间：
2013-02-12
期刊：
影响因子：
6.4
通讯作者：
Marshall BM
中科院分区：
文献类型：
--
作者：
Levy SB;Marshall BM
与动物和人一样，昆虫既可以作为抗生素抗性基因的收集者，也可以作为抗生素抗性基因的传播者，最近的一项研究充分证明了这一点（B. Tian, N. H. Fadhil, J. E. Powell, W. K. Kwong, and N. A. Moran, mBio 3[6]:e00377-12, doi:10.1128/mBio.00377-12, 2012）。值得注意的是，蜜蜂肠道相对封闭的生态系统表现出很大的倾向，含有多种四环素抗性基因，这些基因揭示了蜜蜂产业中四环素使用的长期选择性压力所造成的环境负担。与人类和动物一样，这些基因已经在昆虫肠道的本地非致病菌群中建立，这增加了共生菌群提供大量抗性基因库的概念，这些基因可以很容易地转移到致病物种中。这些四环素抗性决定因素与动物和人类相关的四环素抗性细菌中发现的决定因素的同源性强烈表明相似或相同的基因通过共享生态系统传播。单一抗生素治疗后出现的相关耐药性（氨苄青霉素和四环素）反映了其他研究的报告，即长期单药治疗将导致对多种药物的耐药性。这些结果与未受到这种选择压力的野生和家养蜜蜂明显缺乏多种单一和多重耐药基因形成鲜明对比。同时追踪耐药基因和抗生素残留的前瞻性研究将大大有助于解决一些困扰我们对抗生素耐药性传播的理解的棘手问题。
Like animals and people, insects can serve as both collectors and disseminators of antibiotic resistance genes, as exquisitely demonstrated by a recent study (B. Tian, N. H. Fadhil, J. E. Powell, W. K. Kwong, and N. A. Moran, mBio 3[6]:e00377-12, doi:10.1128/mBio.00377-12, 2012). Notably, the relatively confined ecosystem of the honeybee gut demonstrates a large propensity for harboring a diverse set of tetracycline resistance genes that reveal the environmental burden resulting from the long-time selective pressures of tetracycline use in the honeybee industry. As in humans and animals, these genes have become established in the native, nonpathogenic flora of the insect gut, adding credence to the concept that commensal floras provide large reservoirs of resistance genes that can readily move into pathogenic species. The homology of these tetracycline resistance determinants with those found in tetracycline-resistant bacteria associated with animals and humans strongly suggests a dissemination of similar or identical genes through shared ecosystems. The emergence of linked coresistances (ampicillin and tetracycline) following single-antibiotic therapy mirrors reports from other studies, namely, that long-term, single-agent therapy will result in resistance to multiple drugs. These results contrast with the marked absence of diverse, single- and multiple-drug resistance genes in wild and domestic bees that are not subjected to such selective pressures. Prospective studies that simultaneously track both resistance genes and antibiotic residues will go far in resolving some of the nagging questions that cloud our understanding of antibiotic resistance dissemination.