Dietary glycaemic index and glycaemic load in relation to the risk of type 2 diabetes: a meta-analysis of prospective cohort studies
Dietary glycaemic index and glycaemic load in relation to the risk of type 2 diabetes: a meta-analysis of prospective cohort studies
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DOI：
10.1017/s000711451100540x
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发表时间：
2011-12-01
影响因子：
3.6
通讯作者：
Qin, Li-Qiang
中科院分区：
文献类型：
--
作者：
Dong, Jia-Yi;Zhang, Lijun;Qin, Li-Qiang
饮食代谢指数（GI）和代谢负荷（GL）与糖尿病风险相关的流行病学研究得出了不一致的结果。我们的目的是通过对前瞻性队列研究进行荟萃分析，研究饮食GI和GL与2型糖尿病风险之间的关系。通过PubMed数据库检索确定了截至2011年2月的相关研究。还审查了检索到的文章的参考文献列表。我们纳入了前瞻性队列研究，这些研究报告了饮食GI和GL与2型糖尿病风险之间关系的风险估计值（95% CI）。使用固定效应或随机效应模型计算汇总相对风险（RR）。我们确定了13项饮食GI或GL与糖尿病风险相关的前瞻性队列研究。最高GI类别与最低GI类别相比，2型糖尿病的汇总RR为1.16（95% CI 1.06，1.26; n 12），具有中度异质性证据（P=0.02，I-2=50.8%）。对于GL，汇总RR为1.20（95% CI 1.11，1.30; n 12），几乎没有异质性证据（P=0.10，I-2=34.8%）。未观察到发表偏倚的证据。此外，相关性持续存在，并在敏感性分析中保持统计学显著性。总之，本荟萃分析提供了进一步的证据，支持饮食GI和GL与2型糖尿病风险之间的显著正相关。减少高GI食物的摄入量可能对预防糖尿病有益。
Epidemiological studies of dietary glycaemic index (GI) and glycaemic load (GL) in relation to diabetes risk have yielded inconsistent results. We aimed to examine the associations between dietary GI and GL and the risk of type 2 diabetes by conducting a meta-analysis of prospective cohort studies. Relevant studies were identified by a PubMed database search up to February 2011. Reference lists from retrieved articles were also reviewed. We included prospective cohort studies that reported risk estimates with 95% CI for the associations between dietary GI and GL and the risk of type 2 diabetes. Either a fixed-or random-effects model was used to compute the summary relative risk (RR). We identified thirteen prospective cohort studies of dietary GI or GL related to diabetes risk. The summary RR of type 2 diabetes for the highest category of the GI compared with the lowest was 1.16 (95% CI 1.06, 1.26; n 12), with moderate evidence of heterogeneity (P=0.02, I-2=50.8%). For the GL, the summary RR was 1.20 (95% CI 1.11, 1.30; n 12), with little evidence of heterogeneity (P=0.10, I-2=34.8%). No evidence of publication bias was observed. In addition, the associations persisted and remained statistically significant in the sensitivity analyses. In conclusion, the present meta-analysis provides further evidence in support of significantly positive associations between dietary GI and GL and the risk of type 2 diabetes. Reducing the intake of high-GI foods may bring benefits in diabetes prevention.