Evaluation of gender differences in endothelium-independent dilation using peripheral arterial tonometry.
Evaluation of gender differences in endothelium-independent dilation using peripheral arterial tonometry.
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DOI：
10.1111/j.1475-097x.2011.01060.x
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发表时间：
2012-03
影响因子：
1.8
通讯作者：
Dengel DR
中科院分区：
文献类型：
--
作者：
McCue MC;Marlatt KL;Kelly AS;Steinberger J;Dengel DR
A change in peripheral arterial tonometry (PAT) in response to reactive hyperemia is often used to provide a non-invasive measure of endothelium-dependent dilation (EDD). Reactive hyperemia does not allow one to quantify endothelium-independent dilation (EID), which is part of overall vascular function. Although most research examining vascular function and cardiovascular disease has focused on EDD, there is evidence that cardiovascular risk factors may impair EID. To examine the microvascular vasodilation response to nitroglycerin (NTG) in healthy adults using PAT. Microvascular responses to reactive hyperemia and NTG were evaluated in 86 (41 female, 45 male) healthy subjects (age 37±5 yrs). Beat-to-beat plethysmographic measurements of finger arterial pulse waves were recorded for 5-min following reactive hyperemia. After a 10-min rest period, sublingual NTG (0.4 mg) was administered and PAT signal changes were measured for 10-min. Peak reactive hyperemic index (RHI) and peak NTG-mediated index (NMI) were determined in all subjects. There were no significant gender differences in peak RHI (females: 2.07±0.56 vs. males: 1.91±0.58, P=0.20). Mean peak NMI for all subjects was 2.78 (±1.49). Peak NMI was significantly greater in females than males (3.11±1.59 vs. 2.50±1.34, P=0.05). Time to peak NMI was not significantly different between genders (7-min, 28-s [±1-min, 47-s], vs. 7-min, 14-s [±1-min, 49-s], P=0.58). In this population of healthy adults, peak NMI was significantly greater in females than males. These findings suggest that gender differences exist in the microvascular vasodilation responses to NTG using PAT.
