Strategic Construction of Chiral Helices: Expanded Poly(l-leucine) Containing p-Phenylene Moieties
Strategic Construction of Chiral Helices: Expanded Poly(l-leucine) Containing p-Phenylene Moieties
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手性螺旋的战略构建：含有对亚苯基部分的扩展聚（L-亮氨酸）
DOI：
10.1021/acs.macromol.7b00718
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发表时间：
2017
期刊：
影响因子：
5.5
通讯作者：
Shuichiro Seno
中科院分区：
文献类型：
--
作者：
T. Okamura;Shuichiro Seno
通过逐步延伸或缩聚反应合成了一系列对苯撑和L-亮氨酸交替排列的扩链低聚和聚L-亮氨酸，并通过1H NMR、SEC、ESI-MS、UV和CD光谱进行了表征。通过SEC发现聚合度为约19。每个单体单元，即，展开的L-亮氨酸，表现为具有刚性弯曲体的手性单元。延长的肽链显着增加的CD强度每亚苯基发色团，然而，CD强度在高温下下降。这种合作行为强烈地暗示了二级结构的形成。1H NMR分析表明，在二甲基亚砜的右手螺旋结构。理论计算与这些结果是一致的。
A series of expanded oligo- and poly(l-leucine)s, with an alternating arrangement of p-phenylene moieties and l-leucine residues, were synthesized by stepwise elongation or polycondensation and characterized by 1H NMR, SEC, ESI-MS, UV, and CD spectra. The degree of polymerization was found to be about 19 by SEC. Each monomer unit, i.e., expanded l-leucine, behaved like a chiral unit with a rigid bend body. Elongation of the peptide chain significantly increased the CD intensity per phenylene chromophore; however, the CD intensity decreased at high temperatures. This cooperative behavior strongly suggested the formation of a secondary structure. 1H NMR analysis revealed a right-handed helical structure in dimethyl sulfoxide. The theoretical calculations were consistent with these results.
影响因子：
15
作者：
Shaginian A;Whitby LR;Hong S;Hwang I;Farooqi B;Searcey M;Chen J;Vogt PK;Boger DL
通讯作者：
Boger DL
影响因子：
18.3
作者：
Horne, W. Seth;Gellman, Samuel H.
通讯作者：
Gellman, Samuel H.