Association of UGT2B7 polymorphisms with risk of induced liver injury by anti-tuberculosis drugs in Chinese Han.
Association of UGT2B7 polymorphisms with risk of induced liver injury by anti-tuberculosis drugs in Chinese Han.
复制标题
UGT2B7多态性与中国汉族抗结核药物肝损伤风险的关系
DOI：
10.1177/0394632017733638
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发表时间：
2017-12
影响因子：
3.5
通讯作者：
He JQ
中科院分区：
文献类型：
--
作者：
Chen G;Wu SQ;Feng M;Wang Y;Wu JC;Ji GY;Zhang MM;Liu QQ;He JQ
抗结核药物性肝损伤（ATLI）是结核病治疗过程中常见的并发症。尿苷二磷酸葡萄糖醛酸基转移酶2B 7（UGT 2B 7）是多种药物代谢的重要酶，与药物性肝病的发生密切相关。本研究旨在探讨中国汉族人群UGT 2B 7基因多态性与ATLI的关系。对280例初治肺结核患者进行抗结核治疗后3个月的随访。使用MassARRAY平台对标签单核苷酸多态性（tag-SNP）（rs 10028494和rs7668282）进行基因分型。通过logistic回归分析调整混杂因素，分析tag-SNPs与ATLI风险之间的关联。在这项前瞻性研究中，33例患者失访，24例患者被诊断为ATLI并被视为病例组。其余223例无ATLI的受试者被视为对照组。两组UGT 2B 7等位基因和基因型频率无显著相关性。本研究首次探讨了中国汉族人群UGT 2B 7基因多态性与ATLI的关系。中国汉族人群UGT 2B 7基因多态性与ATLI无显著相关性。
Anti-tuberculosis drug-induced liver injury (ATLI) is common during the treatment of tuberculosis (TB). As an important enzyme in the metabolism of many drugs, UGT2B7 (uridine diphosphate glucuronyl transferase 2B7) was associated with drug-induced liver disorder. This study investigated the association between the polymorphisms of UGT2B7 and ATLI in Chinese Han. Totally, 280 newly diagnosed TB patients had been followed up for 3 months after the prescription of anti-TB therapy. Tag-single-nucleotide polymorphism (tag-SNPs) (rs10028494 and rs7668282) were genotyped with the MassARRAY platform. The associations between tag-SNPs and ATLI risk were analyzed by logistic regression analysis adjusting for confounding factors. In this prospective study, 33 patients were lost to follow-up, and 24 patients were diagnosed with ATLI and considered as the case group. The remaining 223 subjects without ATLI were considered as the control group. No significant association was observed in allele and genotype frequencies of UGT2B7 between the two groups. This study is the first attempt to investigate the association of genetic polymorphisms of UGT2B7 with ATLI in Chinese Han. There is no significant association between UGT2B7 polymorphisms and ATLI in Chinese Han.
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影响因子：
3.7
作者：
Yimer G;Ueda N;Habtewold A;Amogne W;Suda A;Riedel KD;Burhenne J;Aderaye G;Lindquist L;Makonnen E;Aklillu E
通讯作者：
Aklillu E
影响因子：
2.4
作者：
Kim JY;Cheong HS;Park BL;Kim LH;Namgoong S;Kim JO;Kim HD;Kim YH;Chung MW;Han SY;Shin HD
通讯作者：
Shin HD
影响因子：
3.7
作者：
Shang P;Xia Y;Liu F;Wang X;Yuan Y;Hu D;Tu D;Chen Y;Deng P;Cheng S;Zhou L;Ma Y;Zhu L;Gao W;Wang H;Chen D;Yang L;He P;Wu S;Tang S;Lv X;Shu Z;Zhang Y;Yang Z;Chen Y;Li N;Sun F;Li X;He Y;Garner P;Zhan S
通讯作者：
Zhan S
DOI：
10.3760/cma.j.issn.1007-3418.2011.03.012
发表时间：
2011-03-01
影响因子：
--
作者：
Hao, Jin-qi;Chen, Yi;Feng, Fu-min
通讯作者：
Feng, Fu-min
影响因子：
29.4
作者：
Daly, Ann K.;Aithal, Guruprasad P.;Day, Christopher P.
通讯作者：
Day, Christopher P.