A rhodium complex-linked β-barrel protein as a hybrid biocatalyst for phenylacetylene polymerization
A rhodium complex-linked β-barrel protein as a hybrid biocatalyst for phenylacetylene polymerization
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DOI：
10.1039/c2cc35165j
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Hayashi, Takashi
中科院分区：
文献类型：
--
作者：
Onoda, Akira;Fukumoto, Kazuki;Hayashi, Takashi
本课题组最近制备了一种杂化催化剂，它含有Rh(Cp)(CoD)，在Cp配体的周边位置带有马来酰亚胺部分。然后将该化合物通过共价键插入到脱氧核糖核酸突变体(Q96C)的β-桶蛋白支架中。杂化蛋白被发现起到聚合催化剂的作用，并优先产生反式聚苯乙炔(PPA)，尽管没有蛋白质支架的Rh络合物通常产生顺式PPA。
Our group recently prepared a hybrid catalyst containing a rhodium complex, Rh(Cp)(cod), with a maleimide moiety at the peripheral position of the Cp ligand. This compound was then inserted into a beta-barrel protein scaffold of a mutant of aponitrobindin (Q96C) via a covalent linkage. The hybrid protein is found to act as a polymerization catalyst and preferentially yields trans-poly(phenylacetylene) (PPA), although the rhodium complex without the protein scaffold normally produces cis PPA.