The Relation between 6-n-Propylthiouracil Sensitivity and Caries Activity in Schoolchildren
The Relation between 6-n-Propylthiouracil Sensitivity and Caries Activity in Schoolchildren
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DOI：
10.1159/000332432
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发表时间：
2011-01-01
期刊：
影响因子：
4.2
通讯作者：
Cildir, S.
中科院分区：
文献类型：
--
作者：
Oter, B.;Ulukapi, I.;Cildir, S.
龋齿活动性测试被用来评估儿童龋齿的风险。近年来，大多数研究的目的是开发实用，快速，可靠和经济的测试。临床研究表明，对6-正丙基硫氧嘧啶（PROP）苦味的敏感性差异是一种遗传性状，可能影响儿童的营养习惯和龋齿的发展。本研究的目的是探讨学龄儿童的PROP敏感性与龋活动性的关系，并与不同的龋活动性测试进行比较。对120名7~12岁儿童（平均年龄9.97 ± 1.59岁）进行了调查，以确定社会经济状况和口腔卫生习惯、氟摄入量、DMFT、DMFS、DF、DFS、牙菌斑指数和营养习惯。根据儿童龋损图，将儿童分为三组。溶液试验和PROP浸渍滤纸试验一起用于确定PROP灵敏度。在控制了所有相关因素后，逐步回归分析显示，DMFT和dfs评分是PROP的重要决定因素，根据dfs，Cariogram和PROP试验的敏感性分别为0.85和0.70，特异性分别为0.32和0.33。PROP敏感性与DMFT、DMFS和dfs结果呈负相关（p <0.01）。总之，PROP非品尝者比PROP品尝者有更高的患龋风险（p <0.01）。版权所有（C）2011 S. Karger AG，巴塞尔
Caries activity tests are being used to assess caries risk in children. In recent years the purpose of most studies has been to develop practical, quick, reliable and economic tests. Clinical studies showed that the difference in sensitivity to the bitter taste of 6-n-propylthiouracil (PROP) is a heritable trait and may influence children's nutritional habits and caries development. The aim of this study was to investigate the relation between PROP sensitivity and caries activity in schoolchildren, in comparison with different caries activity tests. One hundred and twenty children aged between 7 and 12 years (mean age 9.97 +/- 1.59) were investigated to determine socioeconomic status and oral hygiene habits, fluoride consumption, DMFT, DMFS, df, dfs, plaque indexes, and nutritional habits. Children were divided into three groups according to their caries risk status based on the Cariogram. The solution test and the PROP-impregnated filter paper test were used together to determine PROP sensitivity. After all associated factors had been controlled, stepwise regression analyses revealed that DMFT and dfs scores were important determinants of PROP. According to dfs, the sensitivity of the Cariogram and of PROP tests was 0.85 and 0.70, respectively, and specificity was 0.32 and 0.33, respectively. There was an inverse significant relationship between PROP sensitivity and DMFT, DMFS, and dfs results (p < 0.01). In conclusion, PROP nontasters were significantly more likely to have high caries risk than PROP tasters (p < 0.01). Copyright (C) 2011 S. Karger AG, Basel