Magnetic resonance imaging of ischemic bowel in rabbit model.
Magnetic resonance imaging of ischemic bowel in rabbit model.
复制标题
兔模型缺血性肠的磁共振成像。
DOI：
10.1097/00004424-198802000-00003
复制
发表时间：
1988
影响因子：
6.7
通讯作者：
A. James
中科院分区：
文献类型：
--
作者：
ALAN J. Kaufman;ROBERT W. Tarr;G. Holburn;Michael McCURDY;C. Partain;A. James
急性肠系膜缺血性肠病是一种常见但复杂的疾病，发病率和死亡率高，主要是由于诊断迟缓引起的。我们利用兔模型研究了磁共振成像（MRI）在小肠缺血早期检测中的作用。手术结扎适当的回肠动脉血管供应造成10只家兔的缺血性损伤。在动脉闭塞后的不同时间间隔对动物进行成像。在轴位和冠状面获得多层、T1和t2加权图像。血管闭塞后45分钟，肠去动脉化段出现异常。结果包括：(1)肠壁增厚，(2)t2加权图像上肠道信号强度增加2至3倍，(3)t1加权图像上肠壁信号强度等或轻微增加。MRI似乎是一种敏感的，无创的技术，早期检测肠缺血在兔动物模型。
Acute mesenteric ischemic bowel disease is a common yet complex disorder with high morbidity and mortality rates predominantly caused by delayed diagnosis. We examined the role of magnetic resonance imaging (MRI) in the early detection of small bowel ischemia using the rabbit model. Surgical ligation of the appropriate arterial vascular supply to the ileum of 10 rabbits produced the ischemic compromise. The animals were imaged at different time intervals after the arterial occlusion. Multislice, T1 and T2-weighted images were obtained in axial and coronal planes. Abnormal findings of the dearterialized segment of bowel were visualized as early as 45 minutes after vascular occlusion. The findings consisted of: (1) bowel wall thickening, (2) two- to three-fold increase in signal intensity from bowel on T2-weighted images, and (3) isointensity or slightly increased signal intensity within the bowel wall on T1-weighted images. MRI appears to be a sensitive, noninvasive technique for the early detection of bowel ischemia in the rabbit animal model.