Increased Intraregional Synchronized Neural Activity in Adult Brain After Prolonged Adaptation to High-Altitude Hypoxia: A Resting-State fMRI Study
Increased Intraregional Synchronized Neural Activity in Adult Brain After Prolonged Adaptation to High-Altitude Hypoxia: A Resting-State fMRI Study
复制标题
长期适应高海拔缺氧后成人大脑区域内同步神经活动增加：一项静息态功能磁共振成像研究。
DOI：
10.1089/ham.2015.0104
复制
发表时间：
2016-03-01
影响因子：
2.1
通讯作者：
Zhang, Jiaxing
中科院分区：
文献类型：
--
作者：
Chen, Ji;Fan, Cunxiu;Zhang, Jiaxing
人类的大脑本质上是可塑的，因此它的功能结构可以根据环境压力和生理变化进行重组。然而，在长时间的高海拔（HA）适应过程中，成人大脑中自发神经活动是否发生代偿性改变尚不清楚。采用经过验证的区域均匀性（Reho）方法研究静息状态功能磁共振成像（fMRI）信号的局部同步性。随后进行种子连通性分析。进行认知和生理评估，并与图像指标相关联。与SL对照组相比，HA移民的整体平均Reho显著增加，右侧外外侧感觉运动皮层的区域增加。此外，在HA移民中，在外外侧感觉运动区提取的平均z-Reho值与记忆搜索反应时间呈趋势水平显著负相关。这些观察结果首次提供了长期暴露于透明质酸后，成人大脑自发神经活动恢复能力没有遗传和发育影响的证据。静息状态功能磁共振成像可以为成人长时间环境缺氧适应过程中呼吸和认知补偿的中枢机制提供有价值的信息，为未来的ha适应训练铺平道路。
The human brain is intrinsically plastic such that its functional architecture can be reorganized in response to environmental pressures and physiological changes. However, it remains unclear whether a compensatory modification of spontaneous neural activity occurs in adult brain during prolonged high-altitude (HA) adaptation. In this study, we obtained resting-state functional magnetic resonance (MR) images in 16 adults who have immigrated to Qinghai-Tibet Plateau (2300-4400 m) for 2 years and in 16 age-matched sea level (SL) controls. A validated regional homogeneity (Reho) method was employed to investigate the local synchronization of resting-state functional magnetic resonance imaging (fMRI) signals. Seed connectivity analysis was carried out subsequently. Cognitive and physiological assessments were made and correlated with the image metrics. Compared with SL controls, global mean Reho was significantly increased in HA immigrants as well as a regional increase in the right inferolateral sensorimotor cortex. Furthermore, mean z-Reho value extracted within the inferolateral sensorimotor area showed trend-level significant inverse correlation with memory search reaction time in HA immigrants. These observations, for the first time, provide evidence of adult brain resilience of spontaneous neural activity after long-term HA exposure without inherited and developmental effects. Resting-state fMRI could yield valuable information for central mechanisms underlying respiratory and cognitive compensations in adults during prolonged environmentally hypoxic adaptation, paving the way for future HA-adaptive training.