Longitudinal changes in dopamine transporter uptake scans in progressive apraxia of speech.
Longitudinal changes in dopamine transporter uptake scans in progressive apraxia of speech.
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DOI：
10.1016/j.prdoa.2023.100207
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Josephs, Keith A.
中科院分区：
文献类型：
--
作者：
Utianski, Rene L.;Pham, Nha Trang Thu;Botha, Hugo;Ali, Farwa;Duffy, Joseph R.;Clark, Heather M.;Lowe, Val J.;Whitwell, Jennifer L.;Josephs, Keith A.
40 - 50%的进行性言语失用症患者可能有异常的DaT扫描。DaT的定量测量通常与视觉读数匹配。DaT的纵向变化可能不会映射到临床进展。描述进行性言语失用症（PAOS）患者多巴胺转运体摄取（DaT）扫描结果的定性和定量纵向变化。应用DaTQUANT软件对39例PAOS患者的左右尾状核和壳核进行DaT扫描，其中19例重复扫描。临床放射学印象被用作金标准，用于评价定量测量（左右壳核和尾状核摄取的z评分）是否与横截面上DaT异常和临床损伤的完形印象一致。使用首次和末次可用DaT的测量值评价随时间的变化以及首次访视时定性异常对随时间变化的影响。横截面，16/39例患者的视觉读取异常DaT扫描，与（ab）正常扫描之间的所有定量DaT测量的差异，但没有任何临床措施（言语失用症，失语症，或帕金森氏症）的差异。基线时有正常DaT扫描的三名患者在随后的访视中被解读为异常，同时定量指标发生变化。在组水平，在重复成像的19例患者中，尽管临床指标进展，但未观察到左侧或右侧尾状核或壳核评分的统计学变化。尽管观察到趋势，但首次访视时的异常对随时间的变化率没有统计学影响。大约40 - 50%的PAOS患者已经或将要进行DaT扫描，这些扫描可能在视觉上被视为异常。DaT的定量测量与横截面视觉读数相匹配，但可能无法映射到这些患者中观察到的临床进展，包括帕金森氏症。
40–50% of patients with progressive apraxia of speech may have abnormal DaT scans. Quantitative measures of DaT typically match visual reads. Longitudinal changes on DaT may not map to clinical progression. To describe qualitative and quantitative longitudinal changes in dopamine transporter uptake (DaT) scan findings in progressive apraxia of speech (PAOS) patients. DaTQUANT software was used to quantify uptake in the left and right caudate and putamen in DaT scans of 39 patients with PAOS, 19 with repeat scans. Clinical radiologic impressions were used as the gold standard for evaluating whether quantitative measures (z-score of left and right putamen and caudate uptake) aligned with gestalt impressions of DaT abnormalities and clinical impairments, cross-sectionally. Measures at first and last available DaT were used to evaluate change over time and the influence of qualitative abnormality at first visit on change over time. Cross-sectionally, 16/39 patients had abnormal DaT scans on visual read, with differences in all quantitative DaT measures between those with (ab)normal scans, but without differences in any clinical measures (apraxia of speech, aphasia, or parkinsonism). Three patients that had normal DaT scans at baseline were read as abnormal at subsequent visits, with coinciding change in quantitative measures. At the group level, across the 19 patients with repeat imaging, no statistical change in left or right caudate or putamen scores was observed despite progression of clinical indices. Abnormality at first visit did not statistically influence the rate of change over time, although trends were observed. Approximately 40–50% of patients with PAOS have or will develop DaT scans that may be visually read as abnormal. Quantitative measures of DaT match visual reads cross-sectionally, but may not map to clinical progression, including of parkinsonism, observed in these patients.
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影响因子：
8.6
作者：
Kim, YJ;Ichise, M;Lang, AE
通讯作者：
Lang, AE
DOI：
10.1007/s00259-022-06069-0
发表时间：
2022-12-06
影响因子：
9.1
作者：
Lanfranchi, Francesco;Arnaldi, Dario;Morbelli, Silvia
通讯作者：
Morbelli, Silvia
影响因子：
16.6
作者：
Josephs KA;Duffy JR;Clark HM;Utianski RL;Strand EA;Machulda MM;Botha H;Martin PR;Pham NTT;Stierwalt J;Ali F;Buciuc M;Baker M;Fernandez De Castro CH;Spychalla AJ;Schwarz CG;Reid RI;Senjem ML;Jack CR Jr;Lowe VJ;Bigio EH;Reichard RR;Polley EJ;Ertekin-Taner N;Rademakers R;DeTure MA;Ross OA;Dickson DW;Whitwell JL
通讯作者：
Whitwell JL
DOI：
10.1212/con.0000000000000699
发表时间：
2019-02-01
期刊：
Continuum (Minneapolis, Minn.)
影响因子：
--
作者：
Botha, Hugo;Josephs, Keith A
通讯作者：
Josephs, Keith A
影响因子：
2.5
作者：
Utianski, Rene L.;Duffy, Joseph R.;Josephs, Keith A.
通讯作者：
Josephs, Keith A.