The association between pregnancy weight gain and birthweight: a within-family comparison.
The association between pregnancy weight gain and birthweight: a within-family comparison.
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DOI：
10.1016/s0140-6736(10)60751-9
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发表时间：
2010-09-18
期刊：
影响因子：
168.9
通讯作者：
Currie, Janet
中科院分区：
文献类型：
--
作者：
Ludwig, David S.;Currie, Janet
怀孕期间体重增加过多似乎会增加出生体重和后代日后肥胖的风险。然而，这种关系可能会受到遗传和其他共同影响的影响。我们使用生命统计出生记录来检查1989年至2003年在密歇根州和新泽西州所有已知的出生。我们的样本包括513,501名不止一次怀孕的女性和她们的1,164,750名后代。我们研究了每位女性在两次或两次以上怀孕期间体重增加的差异如何预测其后代的出生体重，使用了受试者内设计来最大限度地减少混淆。我们发现孕期体重增加和出生体重之间的关系非常一致（β 7.35 [95% CI 7.10-7.59], p < 0.0001）。怀孕期间体重增加超过24公斤的妇女的婴儿出生时比体重增加8-10公斤的妇女的婴儿重148.9克（CI 141.7-156.0）。怀孕期间体重增加24公斤以上的妇女与体重增加8-10公斤的妇女相比，生育体重超过4000克的婴儿的比值比为2.26（2.09 - 2.44）。怀孕期间母亲体重增加会增加出生体重，这与遗传因素无关。鉴于出生体重和成年体重之间的明显关系，针对怀孕期间妇女的肥胖预防可能是有必要的。
Excessive pregnancy weight gain appears to increase birth weight and the offspring’s risk for obesity later in life. However, this relationship may be confounded by genetic and other shared influences. We used Vital Statistics Natality records to examine all known births in Michigan and New Jersey from 1989 to 2003. Our sample included 513,501 women who had more than one singleton pregnancy and their 1,164,750 offspring. We examined how differences in weight gain that occurred during two or more pregnancies for each woman predicted the birth weight of her offspring, using a within-subject design to minimize confounding. We found a remarkably consistent relationship between pregnancy weight gain and birth weight (β 7.35 [95% CI 7.10–7.59], p < 0.0001). Infants of women who gain more than 24 kg during pregnancy were 148.9 g (CI 141.7–156.0) heavier at birth, compared to infants of women who gained 8–10 kg. The odds ratio of giving birth to an infant greater than 4000 g was 2.26 (2.09 – 2.44) for a woman who gained more than 24 kg during pregnancy, compared to a woman who gained 8–10 kg. Maternal weight gain during pregnancy increases birth weight independent of genetic factors. In view of the apparent relationship between birth weight and adult weight, obesity prevention targeted to woman during pregnancy may be warranted.