FUNCTIONAL MAPPING OF THE HUMAN VISUAL-CORTEX BY MAGNETIC-RESONANCE-IMAGING
FUNCTIONAL MAPPING OF THE HUMAN VISUAL-CORTEX BY MAGNETIC-RESONANCE-IMAGING
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DOI：
10.1126/science.1948051
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发表时间：
1991-11-01
期刊：
影响因子：
56.9
通讯作者：
ROSEN, BR
中科院分区：
文献类型：
--
作者：
BELLIVEAU, JW;KENNEDY, DN;ROSEN, BR
由于生理功能、能量代谢和局部血供之间存在明确的相互关系，脑区域血流动力学知识在生理学研究和临床评估中都有广泛的应用。磁共振技术用于脑血流动力学的定量成像，允许在休息和激活认知状态下测量区域脑血容量。这项技术被用来生成人类任务激活的第一个功能性磁共振图，通过使用视觉刺激范式。在光刺激期间，在初级视觉皮层检测到局部血容量增加（32 +/- 10%,n = 7名受试者）。报道了脑钙状裂平面内的质心坐标和脑活动的线性范围。
Knowledge of regional cerebral hemodynamics has widespread application for both physiological research and clinical assessment because of the well-established interrelation between physiological function, energy metabolism, and localized blood supply. A magnetic resonance technique was developed for quantitative imaging of cerebral hemodynamics, allowing for measurement of regional cerebral blood volume during resting and activated cognitive states. This technique was used to generate the first functional magnetic resonance maps of human task activation, by using a visual stimulus paradigm. During photic stimulation, localized increases in blood volume (32 +/- 10 percent, n = 7 subjects) were detected in the primary visual cortex. Center-of-mass coordinates and linear extents of brain activation within the plane of the calcarine fissure are reported.