DIRECT RELATIONSHIP BETWEEN BLOOD-PRESSURE AND BLOOD-VISCOSITY IN NORMAL AND HYPERTENSIVE SUBJECTS - ROLE OF FIBRINOGEN AND CONCENTRATION
DIRECT RELATIONSHIP BETWEEN BLOOD-PRESSURE AND BLOOD-VISCOSITY IN NORMAL AND HYPERTENSIVE SUBJECTS - ROLE OF FIBRINOGEN AND CONCENTRATION
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DOI：
10.1016/0002-9343(81)90827-5
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发表时间：
1981-01-01
影响因子：
5.9
通讯作者：
LARAGH, JH
中科院分区：
文献类型：
--
作者：
LETCHER, RL;CHIEN, S;LARAGH, JH
本文测定了49例正常人和49例原发性高血压患者的血压和血液粘度。6种切变率下的血液粘度值与血压呈显著相关（r = 0.432-0.505，P < 0.001）。高血压患者血液粘度增高。这是由于较高的血浆粘度（1.29 ± 0.001）。0.08与1.24 .+-相比。0.05厘泊（cP），P < 0.001）和增加的血细胞比容值（44.4 ± 0.01）。4对41.5 ±。3%，P < 0.005）。当在具有匹配的红细胞压积值的正常和高血压受试者的亚组中评估血液粘度时，高血压患者的血液粘度仍然较高。血压与血粘度的关系仍有显著性。无论红细胞压积值如何，高血压患者的纤维蛋白原水平均升高（P < 0.006），并且与球蛋白浓度升高相关，纤维蛋白原是高血压患者血浆粘度升高的主要原因。由于正常人和高血压患者的去纤维蛋白原血粘度相似，血细胞比容值匹配，因此纤维蛋白原水平升高会影响全血粘度。去甲肾上腺素血粘度与动脉压无相关性。血压正常者和高血压者的血压和血液粘度之间存在直接相关性。这种关系部分是由于纤维蛋白原水平升高的流变学效应和红细胞压积值升高。高血压患者高纤维蛋白原血症的基础尚不清楚。
Blood pressure and components of blood viscosity were measured in 49 normal subjects and in 49 untreated patients with essential hypertension. Blood viscosity values measured at 6 different shear rates were significantly correlated with blood pressure (r = 0.432-0.505, P < 0.001). Blood viscosity was higher in hypertensive patients. This was due to higher plasma viscosity (1.29 .+-. 0.08 vs. 1.24 .+-. 0.05 centipoise (cP), P < 0.001) and increased hematocrit values (44.4 .+-. 4 vs. 41.5 .+-. 3%, P < 0.005). When blood viscosity was evaluated in subgroups of normal and hypertensive subjects with matched hematocrit values, it remained higher in the hypertensive patients. The relationship between blood pressure and viscosity was still significant. Regardless of the hematocrit value, fibrinogen levels were elevated in hypertensive patients (P < 0.006) and, in association with the increased globulin concentration, fibrinogen was largely responsible for the increased plasma viscosity in hypertensive patients. Since the viscosity of defibrinated blood was similar in normal and hypertensive subjects with matched hematocrit values, the elevated fibrinogen level affected whole blood viscosity. Defibrinated blood viscosity and arterial pressures were not correlated. A direct correlation between blood pressure and blood viscosity was demonstrated among normotensive and hypertensive subjects. This relationship is, in part, due to the rheologic effects of an elevated fibrinogen level and to an increased hematocrit value. The basis for hyperfibrinogenemia in hypertensive patients is unclear.