Age-Related Primary Cochlear Neuronal Degeneration in Human Temporal Bones
Age-Related Primary Cochlear Neuronal Degeneration in Human Temporal Bones
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DOI：
10.1007/s10162-011-0283-2
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发表时间：
2011-12-01
影响因子：
2.4
通讯作者：
Merchant, Saumil N.
中科院分区：
文献类型：
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作者：
Makary, Chadi A.;Shin, Jennifer;Merchant, Saumil N.
在获得性感觉神经性听力丧失的情况下，耳蜗神经元的死亡被认为主要是由于感觉细胞的丧失。然而，最近关于声学过度暴露的研究报告称，尽管毛细胞完全存活，但耳蜗神经仍大量退化(Kujawa和Liberman，J Neurosci 29：14077-14085,2009年)。为了评估人耳螺旋神经节细胞(SGCs)的原发缺失，对100名新生儿至100岁的100个人的颞骨进行了神经元计数，其中只包括内、外毛细胞数量正常的病例。神经节细胞数量以平均每年100个细胞的速度下降。没有显著的性别或耳间差异，在基转和上转中退变的轻微增加也没有统计学意义。与年龄相关的SGCs的下降明显小于包括毛细胞缺失的耳朵在内的先前研究(Otte等人，Laryngcope 88：1231-1246,1978)，但显著高于在没有前庭毛细胞缺失的病例中关于前庭神经节细胞的类似数据(Velazquez-Villasenor等，Ann Otol Rhinol Laryngol Suppl 181：14-19,2000)。与年龄相关的SGC计数的下降可能是众所周知的噪声中听力下降的原因，这些数据将有助于解释患有已知耳科疾病的颞骨的组织病理学结果。
In cases of acquired sensorineural hearing loss, death of cochlear neurons is thought to arise largely as a result of sensory-cell loss. However, recent studies of acoustic overexposure report massive degeneration of the cochlear nerve despite complete hair cell survival (Kujawa and Liberman, J Neurosci 29:14077-14085, 2009). To assess the primary loss of spiral ganglion cells (SGCs) in human ears, neuronal counts were performed in 100 temporal bones from 100 individuals, aged newborn to 100 years, selected to include only cases with a normal population of inner and outer hair cells. Ganglion cell counts declined at a mean rate of 100 cells per year of life. There were no significant gender or inter-aural differences, and a slight increase in degeneration in the basal turn re upper turns was not statistically significant. The age-related decline in SGCs was significantly less than that in prior studies that included ears with hair cell loss (Otte et al., Laryngoscope 88:1231-1246, 1978), but significantly more than for analogous data on vestibular ganglion cells in cases without vestibular hair cell loss (Velazquez-Villasenor et al., Ann Otol Rhinol Laryngol Suppl 181:14-19, 2000). The age-related decline in SGC counts may contribute to the well-known decline in hearing-in-noise performance, and the data will help in interpretation of histopathological findings from temporal bones with known otologic disease.