Increased distractor vulnerability but preserved vigilance in patients with schizophrenia: Evidence from a translational Sustained Attention Task
Increased distractor vulnerability but preserved vigilance in patients with schizophrenia: Evidence from a translational Sustained Attention Task
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DOI：
10.1016/j.schres.2013.01.003
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发表时间：
2013-03-01
影响因子：
4.5
通讯作者：
Lustig, Cindy
中科院分区：
文献类型：
--
作者：
Demeter, Elise;Guthrie, Sally K.;Lustig, Cindy
目的：注意缺陷是精神分裂症的核心认知损害。分心条件持续注意力任务（dSAT）已被认知神经科学治疗，以提高认知精神分裂症（CNTRICS）倡议确定为一个有前途的翻译任务，用于评估精神分裂症相关的缺陷，在注意力选择控制，识别这种缺陷的神经影像学生物标志物，并为潜在的促认知治疗的临床前动物研究。在这里，我们研究了患者是否会表现出特定的困难，在选择控制和避免分心的dSAT.Method：选择控制赤字的持续注意力任务（SAT）没有分心的任务时，分心（dSAT）的性能进行比较的注意力表现。基线SAT条件还可用于评估任务时间或警惕性影响。精神分裂症患者，年龄和性别相匹配的健康对照，并作为额外的控制，学龄儿童进行了测试的SAT和dSAT.Results：与健康对照组相比，患者的整体性能下降，并差异易受分心。相反，患者，但不是儿童保留了警惕随着时间的推移。结论：这些结果表明，具体的输入选择控制障碍精神分裂症，并建议，患者的分心相关的损害，可以区分一般的性能障碍和赤字在其他注意过程（如：例如，在一个实施例中，注意力集中在其他群体。(C)2013年由Elsevier B.V.出版
Objective: Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophrenia-related deficits in attentional selection-control, identifying neuroimaging biomarkers of such deficits, and for preclinical animal research on potential pro-cognitive treatments. Here, we examined whether patients would show specific difficulties in selection-control and in avoiding distraction in the dSAT.Method: Selection-control deficits are measured by comparing attentional performance in the Sustained Attention Task (SAT) without distraction to performance on the task when distraction is present (dSAT). The baseline SAT condition can also be used to assess time-on-task or vigilance effects. Patients with schizophrenia, age-and gender-matched healthy controls and, as an additional control, school-aged children were tested on both the SAT and dSAT.Results: Compared to healthy controls, patients had reduced performance overall and were differentially vulnerable to distraction. In contrast, patients but not children had preserved vigilance over time.Conclusion: These results demonstrate specific input-selection control impairments in schizophrenia and suggest that patients' distraction-related impairments can be distinguished from general performance impairments and from deficits in other attentional processes (e. g., sustaining attention) evident in other groups. (C) 2013 Published by Elsevier B.V.