Laterodorsal nucleus of the thalamus: A processor of somatosensory inputs
Laterodorsal nucleus of the thalamus: A processor of somatosensory inputs
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DOI：
10.1002/cne.21664
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发表时间：
2008-04-20
影响因子：
2.5
通讯作者：
Keller, Asaf
中科院分区：
文献类型：
--
作者：
Bezdudnaya, Tatiana;Keller, Asaf
丘脑的背外侧核（LD）被认为是向边缘皮质区提供输入的“高级”核团。虽然它的功能在很大程度上是未知的，它通常被认为是参与空间学习和记忆。在这里，我们提供的证据表明，LD是一个迄今为止未知的途径处理体感信息的一部分。LD神经元的近细胞和细胞外记录显示，它们对触须刺激的反应具有短潜伏期（中位数= 7 ms）和大幅度的反应（中位数= 1.2尖峰/刺激）。大多数神经元（62%）有大的感受野，响应六个或更多个人的触须。电刺激三叉神经极间核（SpVi）诱发短潜伏期反应（中位数= 3.8 ms）vibrissasresponsive LD神经元。顺行和逆行神经解剖示踪剂产生的标签证实，LD神经元接收直接输入SpVi。电生理学和神经解剖学分析也表明，LD的项目上扣带和压后皮质，但只有稀疏的预测桶皮质。这些研究结果表明，LD是一个新的加工流的一部分，涉及空间定位和学习相关的体感线索。
The laterodorsal (LD) nucleus of the thalamus has been considered a "higher order" nucleus that provides inputs to limbic cortical areas. Although its functions are largely unknown, it is often considered to be involved in spatial learning and memory. Here we provide evidence that LD is part of a hitherto unknown pathway for processing somatosensory information. Juxtacellular and extracellular recordings from LD neurons reveal that they respond to vibrissa stimulation with short latency (median = 7 ms) and large magnitude responses (median = 1.2 spikes/stimulus). Most neurons (62%) had large receptive fields, responding to six and more individual vibrissae. Electrical stimulation of the trigeminal nucleus interpolaris (SpVi) evoked short latency responses (median = 3.8 ms) in vibrissaresponsive LD neurons. Labeling produced by anterograde and retrograde neuroanatomical tracers confirmed that LD neurons receive direct inputs from SpVi. Electrophysiological and neuroanatomical analyses revealed also that LD projects upon the cingulate and retrosplenial cortex, but has only sparse projections to the barrel cortex. These findings suggest that LD is part of a novel processing stream involved in spatial orientation and learning related to somatosensory cues.