Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population
Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population
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DOI：
10.1161/01.atv.19.7.1734
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发表时间：
1999-07-01
影响因子：
8.7
通讯作者：
Ordovas, JM
中科院分区：
文献类型：
--
作者：
Acton, S;Osgood, D;Ordovas, JM
The scavenger receptor class B type I (SR-BI) is a lipoprotein receptor that has been shown to be important in high density lipoprotein cholesterol (HDL-C) metabolism in mice. To determine its role in humans, we have characterized the human SR-BI gene and investigated its genetic variation in 489 white men and women. Five variants were demonstrated: 2 in introns (3 and 5) and 3 in exons (1, 8, and ii). Three variants at exons 1 and 8 and intron 5 with allele frequencies >0.1 were used to examine associations with lipid or anthropometric variables. The exon 1 variant was significantly (P
