Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone
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DOI：
10.1038/nn.3963
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发表时间：
2015-04-01
影响因子：
25
通讯作者：
Ninkovic, Jovica
中科院分区：
文献类型：
--
作者：
Calzolari, Filippo;Michel, Julia;Ninkovic, Jovica
我们分析了小鼠成体室管膜下区（SEZ）的单个神经干细胞（NSC）的后代，发现了一个显着快速的谱系扩增，以及有限的NSC自我更新和耗尽在几周内。我们进一步揭示了神经元亚型产生的机制，发现更高比例的NSC致力于在嗅球中产生深层颗粒细胞，并且这些NSC产生更大的克隆。
We analyzed the progeny of individual neural stem cells (NSCs) of the mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well as limited NSC self-renewal and exhaustion in a few weeks. We further unraveled the mechanisms of neuronal subtype generation, finding that a higher proportion of NSCs were dedicated to generate deep granule cells in the olfactory bulb and that larger clones were produced by these NSCs.